Transplantation of CD34+ Hematopoietic Progenitor Cells

Elizabeth J. Shpall; Roy B. Jones; Scott I. Bearman; Malcolm H. Purdy; Wilbur A. Franklin; Shelly Heimfeld; Ronald J. Berenson

doi:10.1089/scd.1.1994.3.145

Transplantation of CD34⁺ Hematopoietic Progenitor Cells

Elizabeth J. Shpall, Roy B. Jones, Scott I. Bearman, Malcolm H. Purdy, Wilbur A. Franklin, Shelly Heimfeld, Ronald J. Berenson

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Sixty-six stage IV breast cancer patients received high dose chemotherapy followed by autologous transplantation of CD34-positive (+) cells obtained from the bone marrow and/or granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood. Grafts were examined for the presence of tumor using conventional histology and immunocytochemical staining. Patients achieved a granulocyte count of 500 x 10⁹/liter 10-12 days posttransplant, with a platelet count of >20 x 10⁹/liter in 14-15 days. Enrichment of CD34⁺ cells from the peripheral blood progenitor cell (PBPC) collections resulted in a 1.3 to 4.0 log depletion of breast cancer cells from the graft.

Original language	English (US)
Pages (from-to)	145-147
Number of pages	3
Journal	Journal of Hematotherapy and Stem Cell Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1089/scd.1.1994.3.145
State	Published - 1994

ASJC Scopus subject areas

Immunology
Hematology

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title = "Transplantation of CD34+ Hematopoietic Progenitor Cells",

abstract = "Sixty-six stage IV breast cancer patients received high dose chemotherapy followed by autologous transplantation of CD34-positive (+) cells obtained from the bone marrow and/or granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood. Grafts were examined for the presence of tumor using conventional histology and immunocytochemical staining. Patients achieved a granulocyte count of 500 x 109/liter 10-12 days posttransplant, with a platelet count of >20 x 109/liter in 14-15 days. Enrichment of CD34+ cells from the peripheral blood progenitor cell (PBPC) collections resulted in a 1.3 to 4.0 log depletion of breast cancer cells from the graft.",

author = "Shpall, {Elizabeth J.} and Jones, {Roy B.} and Bearman, {Scott I.} and Purdy, {Malcolm H.} and Franklin, {Wilbur A.} and Shelly Heimfeld and Berenson, {Ronald J.}",

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T1 - Transplantation of CD34+ Hematopoietic Progenitor Cells

AU - Shpall, Elizabeth J.

AU - Jones, Roy B.

AU - Bearman, Scott I.

AU - Purdy, Malcolm H.

AU - Franklin, Wilbur A.

AU - Heimfeld, Shelly

AU - Berenson, Ronald J.

PY - 1994

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AB - Sixty-six stage IV breast cancer patients received high dose chemotherapy followed by autologous transplantation of CD34-positive (+) cells obtained from the bone marrow and/or granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood. Grafts were examined for the presence of tumor using conventional histology and immunocytochemical staining. Patients achieved a granulocyte count of 500 x 109/liter 10-12 days posttransplant, with a platelet count of >20 x 109/liter in 14-15 days. Enrichment of CD34+ cells from the peripheral blood progenitor cell (PBPC) collections resulted in a 1.3 to 4.0 log depletion of breast cancer cells from the graft.

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Transplantation of CD34⁺ Hematopoietic Progenitor Cells

Abstract

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