Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas

Andrew M. Heitzer; Lisa S. Kahalley; Charles G. Minard; Claire Stafford; David R. Grosshans; M. Fatih Okcu; Kimberly P. Raghubar; Marsha Gragert; Mark McCurdy; Emily H. Warren; Jocelyn Gomez; M. Douglas Ris; Arnold C. Paulino; Murali Chintagumpala

doi:10.1002/pbc.29096

Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas

Andrew M. Heitzer, Lisa S. Kahalley, Charles G. Minard, Claire Stafford, David R. Grosshans, M. Fatih Okcu, Kimberly P. Raghubar, Marsha Gragert, Mark McCurdy, Emily H. Warren, Jocelyn Gomez, M. Douglas Ris, Arnold C. Paulino, Murali Chintagumpala

Radiation Oncology

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3 Scopus citations

Abstract

The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥.142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.

Original language	English (US)
Article number	e29096
Journal	Pediatric Blood and Cancer
Volume	68
Issue number	8
DOIs	https://doi.org/10.1002/pbc.29096
State	Published - Aug 2021

Keywords

cognition
low-grade glioma
pediatric brain tumor
proton radiotherapy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Heitzer, A. M., Kahalley, L. S., Minard, C. G., Stafford, C., Grosshans, D. R., Okcu, M. F., Raghubar, K. P., Gragert, M., McCurdy, M., Warren, E. H., Gomez, J., Ris, M. D., Paulino, A. C., & Chintagumpala, M. (2021). Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas. Pediatric Blood and Cancer, 68(8), Article e29096. https://doi.org/10.1002/pbc.29096

Heitzer, AM, Kahalley, LS, Minard, CG, Stafford, C, Grosshans, DR, Okcu, MF, Raghubar, KP, Gragert, M, McCurdy, M, Warren, EH, Gomez, J, Ris, MD, Paulino, AC & Chintagumpala, M 2021, 'Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas', Pediatric Blood and Cancer, vol. 68, no. 8, e29096. https://doi.org/10.1002/pbc.29096

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abstract = "The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥.142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.",

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author = "Heitzer, {Andrew M.} and Kahalley, {Lisa S.} and Minard, {Charles G.} and Claire Stafford and Grosshans, {David R.} and Okcu, {M. Fatih} and Raghubar, {Kimberly P.} and Marsha Gragert and Mark McCurdy and Warren, {Emily H.} and Jocelyn Gomez and Ris, {M. Douglas} and Paulino, {Arnold C.} and Murali Chintagumpala",

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AU - Grosshans, David R.

AU - Okcu, M. Fatih

AU - Raghubar, Kimberly P.

AU - Gragert, Marsha

AU - McCurdy, Mark

AU - Warren, Emily H.

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AU - Ris, M. Douglas

AU - Paulino, Arnold C.

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Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas

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