Treatment of acute leukemia with 5 azacytidine (NSC 102816)

K. B. McCredie; G. P. Bodey; M. A. Burgess; J. U. Gutterman; V. Rodriguez; M. P. Sullivan; E. J. Freireich

Treatment of acute leukemia with 5 azacytidine (NSC 102816)

K. B. McCredie, G. P. Bodey, M. A. Burgess, J. U. Gutterman, V. Rodriguez, M. P. Sullivan, E. J. Freireich

Leukemia

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93 Scopus citations

Abstract

5 Azacytidine was administered to 28 patients with acute leukemia and 4 patients with chronic myelogenous leukemia in blast cell crisis, all but one of whom had received extensive prior therapy. Four complete and 4 partial remissions were achieved in 29 patients evaluable for response. The median duration of complete remission was 19 wk. Nausea, vomiting, and diarrhea were common. Hypotension following administration of the drug occurred in 4 patients, and in one case this was fatal.

Original language	English (US)
Pages (from-to)	319-323
Number of pages	5
Journal	CANCER CHEMOTHER.REP.
Volume	57
Issue number	3
State	Published - 1973

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Treatment of acute leukemia with 5 azacytidine (NSC 102816)",

abstract = "5 Azacytidine was administered to 28 patients with acute leukemia and 4 patients with chronic myelogenous leukemia in blast cell crisis, all but one of whom had received extensive prior therapy. Four complete and 4 partial remissions were achieved in 29 patients evaluable for response. The median duration of complete remission was 19 wk. Nausea, vomiting, and diarrhea were common. Hypotension following administration of the drug occurred in 4 patients, and in one case this was fatal.",

author = "McCredie, {K. B.} and Bodey, {G. P.} and Burgess, {M. A.} and Gutterman, {J. U.} and V. Rodriguez and Sullivan, {M. P.} and Freireich, {E. J.}",

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language = "English (US)",

volume = "57",

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T1 - Treatment of acute leukemia with 5 azacytidine (NSC 102816)

AU - McCredie, K. B.

AU - Bodey, G. P.

AU - Burgess, M. A.

AU - Gutterman, J. U.

AU - Rodriguez, V.

AU - Sullivan, M. P.

AU - Freireich, E. J.

PY - 1973

Y1 - 1973

N2 - 5 Azacytidine was administered to 28 patients with acute leukemia and 4 patients with chronic myelogenous leukemia in blast cell crisis, all but one of whom had received extensive prior therapy. Four complete and 4 partial remissions were achieved in 29 patients evaluable for response. The median duration of complete remission was 19 wk. Nausea, vomiting, and diarrhea were common. Hypotension following administration of the drug occurred in 4 patients, and in one case this was fatal.

AB - 5 Azacytidine was administered to 28 patients with acute leukemia and 4 patients with chronic myelogenous leukemia in blast cell crisis, all but one of whom had received extensive prior therapy. Four complete and 4 partial remissions were achieved in 29 patients evaluable for response. The median duration of complete remission was 19 wk. Nausea, vomiting, and diarrhea were common. Hypotension following administration of the drug occurred in 4 patients, and in one case this was fatal.

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AN - SCOPUS:0015844307

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JF - CANCER CHEMOTHER.REP.

IS - 3

ER -

Treatment of acute leukemia with 5 azacytidine (NSC 102816)

Abstract

ASJC Scopus subject areas

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