Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia

Elias Anaissie; Kenneth Rolston; Gerald P. Bodey; Philip A. Pizzo; Marc Rubin; Jean Luc Pellegrin; Gerald Marit; Jeannette Texier; Bernard Leng; Josy Reiffers; T. Calandra; M. P. Glauser; J. Klastersky; H. Gaya; S. H. Zinner; F. Meunier

doi:10.1056/NEJM198806233182514

Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia

Elias Anaissie, Kenneth Rolston, Gerald P. Bodey, Philip A. Pizzo, Marc Rubin, Jean Luc Pellegrin, Gerald Marit, Jeannette Texier, Bernard Leng, Josy Reiffers, T. Calandra, M. P. Glauser, J. Klastersky, H. Gaya, S. H. Zinner, F. Meunier

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: Antibiotic therapy for patients with fever and neutropenia remains controversial.¹ The most recent trial conducted by the European Organization for Research and Treatment of Cancer (EORTC) concluded that ceftazidime given in combination with a full course of amikacin was superior to ceftazidime plus a short course of treatment with amikacin for gram-negative bacillary bacteremias, and that the former combination should be used empirically in febrile patients with neutropenia (Dec. 31 issue).² The response rate (81 percent) reported with the full-course amikacin regimen is similar to that reported in various studies.³ ⁴ ⁵ ⁶ ⁷ ⁸ ⁹ The poor response rate (48 percent) with.

Original language	English (US)
Pages (from-to)	1694-1696
Number of pages	3
Journal	New England Journal of Medicine
Volume	318
Issue number	25
DOIs	https://doi.org/10.1056/NEJM198806233182514
State	Published - Jun 23 1988

ASJC Scopus subject areas

General Medicine

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Anaissie, E., Rolston, K., Bodey, G. P., Pizzo, P. A., Rubin, M., Pellegrin, J. L., Marit, G., Texier, J., Leng, B., Reiffers, J., Calandra, T., Glauser, M. P., Klastersky, J., Gaya, H., Zinner, S. H., & Meunier, F. (1988). Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia. New England Journal of Medicine, 318(25), 1694-1696. https://doi.org/10.1056/NEJM198806233182514

Anaissie, E, Rolston, K, Bodey, GP, Pizzo, PA, Rubin, M, Pellegrin, JL, Marit, G, Texier, J, Leng, B, Reiffers, J, Calandra, T, Glauser, MP, Klastersky, J, Gaya, H, Zinner, SH & Meunier, F 1988, 'Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia', New England Journal of Medicine, vol. 318, no. 25, pp. 1694-1696. https://doi.org/10.1056/NEJM198806233182514

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title = "Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia",

abstract = "To the Editor: Antibiotic therapy for patients with fever and neutropenia remains controversial.1 The most recent trial conducted by the European Organization for Research and Treatment of Cancer (EORTC) concluded that ceftazidime given in combination with a full course of amikacin was superior to ceftazidime plus a short course of treatment with amikacin for gram-negative bacillary bacteremias, and that the former combination should be used empirically in febrile patients with neutropenia (Dec. 31 issue).2 The response rate (81 percent) reported with the full-course amikacin regimen is similar to that reported in various studies.3 4 5 6 7 8 9 The poor response rate (48 percent) with.",

author = "Elias Anaissie and Kenneth Rolston and Bodey, {Gerald P.} and Pizzo, {Philip A.} and Marc Rubin and Pellegrin, {Jean Luc} and Gerald Marit and Jeannette Texier and Bernard Leng and Josy Reiffers and T. Calandra and Glauser, {M. P.} and J. Klastersky and H. Gaya and Zinner, {S. H.} and F. Meunier",

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doi = "10.1056/NEJM198806233182514",

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AU - Anaissie, Elias

AU - Rolston, Kenneth

AU - Bodey, Gerald P.

AU - Pizzo, Philip A.

AU - Rubin, Marc

AU - Pellegrin, Jean Luc

AU - Marit, Gerald

AU - Texier, Jeannette

AU - Leng, Bernard

AU - Reiffers, Josy

AU - Calandra, T.

AU - Glauser, M. P.

AU - Klastersky, J.

AU - Gaya, H.

AU - Zinner, S. H.

AU - Meunier, F.

PY - 1988/6/23

Y1 - 1988/6/23

N2 - To the Editor: Antibiotic therapy for patients with fever and neutropenia remains controversial.1 The most recent trial conducted by the European Organization for Research and Treatment of Cancer (EORTC) concluded that ceftazidime given in combination with a full course of amikacin was superior to ceftazidime plus a short course of treatment with amikacin for gram-negative bacillary bacteremias, and that the former combination should be used empirically in febrile patients with neutropenia (Dec. 31 issue).2 The response rate (81 percent) reported with the full-course amikacin regimen is similar to that reported in various studies.3 4 5 6 7 8 9 The poor response rate (48 percent) with.

AB - To the Editor: Antibiotic therapy for patients with fever and neutropenia remains controversial.1 The most recent trial conducted by the European Organization for Research and Treatment of Cancer (EORTC) concluded that ceftazidime given in combination with a full course of amikacin was superior to ceftazidime plus a short course of treatment with amikacin for gram-negative bacillary bacteremias, and that the former combination should be used empirically in febrile patients with neutropenia (Dec. 31 issue).2 The response rate (81 percent) reported with the full-course amikacin regimen is similar to that reported in various studies.3 4 5 6 7 8 9 The poor response rate (48 percent) with.

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JO - New England Journal of Medicine

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Treatment of Gram-Negative Bacteremia in Patients with Cancer and Granulocytopenia

Abstract

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