TY - JOUR
T1 - Treatment of invasive aspergillus sinusitis with liposomal-amphotericin B
AU - Weber, Randal S.
AU - Lopez-Berestein, Gabriel
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1987/8
Y1 - 1987/8
N2 - Invasive sinonasal aspergillosis is a severe and frequently fatal infection in immunosuppressed patients with hematologic malignancies. Seven patients with sinonasal aspergillosis who failed to respond to conventional amphotericin B (AmpB) were treated with liposomal AmpB (L-AmpB). AmpB was incorporated into multilamellar vesicles consisting of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol in a 7:3 molar ratio. Five patients had underlying hematologic malignancies, one patient had aplastic anemia, and one patient had no underlying disease. All patients had biopsy-proven invasive Aspergillus sinusitis, and had failed conventional antifungal therapy including AmpB. Five patients were cured and two did not respond to treatment. Fever and chills were infrequent and, when they occurred, mild, and responded well to conventional management. No severe renal or central nervous system toxicity was observed. L-AmpB is effective and less toxic than conventional AmpB in the treatment of invasive Aspergillus sinusitis.
AB - Invasive sinonasal aspergillosis is a severe and frequently fatal infection in immunosuppressed patients with hematologic malignancies. Seven patients with sinonasal aspergillosis who failed to respond to conventional amphotericin B (AmpB) were treated with liposomal AmpB (L-AmpB). AmpB was incorporated into multilamellar vesicles consisting of dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol in a 7:3 molar ratio. Five patients had underlying hematologic malignancies, one patient had aplastic anemia, and one patient had no underlying disease. All patients had biopsy-proven invasive Aspergillus sinusitis, and had failed conventional antifungal therapy including AmpB. Five patients were cured and two did not respond to treatment. Fever and chills were infrequent and, when they occurred, mild, and responded well to conventional management. No severe renal or central nervous system toxicity was observed. L-AmpB is effective and less toxic than conventional AmpB in the treatment of invasive Aspergillus sinusitis.
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U2 - 10.1288/00005537-198708000-00010
DO - 10.1288/00005537-198708000-00010
M3 - Article
C2 - 3613794
AN - SCOPUS:0023609545
SN - 0023-852X
VL - 97
SP - 937
EP - 941
JO - Laryngoscope
JF - Laryngoscope
IS - 8
ER -