Treatment of ovarian cancer with a tropism modified oncolytic adenovirus

Gerd J. Bauerschmitz; John T. Lam; Anna Kanerva; Kaori Suzuki; Dirk M. Nettelbeck; Igor Dmitriev; Victor Krasnykh; Galina V. Mikheeva; Mack N. Barnes; Ronald D. Alvarez; Peter Dall; Ramon Alemany; David T. Curiel; Akseli Hemminki

Treatment of ovarian cancer with a tropism modified oncolytic adenovirus

Gerd J. Bauerschmitz, John T. Lam, Anna Kanerva, Kaori Suzuki, Dirk M. Nettelbeck, Igor Dmitriev, Victor Krasnykh, Galina V. Mikheeva, Mack N. Barnes, Ronald D. Alvarez, Peter Dall, Ramon Alemany, David T. Curiel, Akseli Hemminki

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Ad5-Δ24RGD is an adenovirus that is selectively replication competent in cells defective in the Rb/p16 pathway, such as ovarian cancer cells. The fiber of Ad5-Δ24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of cancer cells. Oncolysis of cell lines was similar to that of a wild-type control, and replication in primary tumor material was shown using a novel three-dimensional spheroid model. Finally, an orthotopic murine model of peritoneally disseminated ovarian cancer was used to test i.p. administration to tumor-bearing animals. Injection of the agent resulted in eradication of i.p. disease, whereas control animals expired (P < 0.0001). These results suggest that Ad5-Δ24RGD could be useful for treatment of ovarian cancer in humans.

Original language	English (US)
Pages (from-to)	1266-1270
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	5
State	Published - Mar 1 2002

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Treatment of ovarian cancer with a tropism modified oncolytic adenovirus",

abstract = "Ad5-Δ24RGD is an adenovirus that is selectively replication competent in cells defective in the Rb/p16 pathway, such as ovarian cancer cells. The fiber of Ad5-Δ24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of cancer cells. Oncolysis of cell lines was similar to that of a wild-type control, and replication in primary tumor material was shown using a novel three-dimensional spheroid model. Finally, an orthotopic murine model of peritoneally disseminated ovarian cancer was used to test i.p. administration to tumor-bearing animals. Injection of the agent resulted in eradication of i.p. disease, whereas control animals expired (P < 0.0001). These results suggest that Ad5-Δ24RGD could be useful for treatment of ovarian cancer in humans.",

author = "Bauerschmitz, {Gerd J.} and Lam, {John T.} and Anna Kanerva and Kaori Suzuki and Nettelbeck, {Dirk M.} and Igor Dmitriev and Victor Krasnykh and Mikheeva, {Galina V.} and Barnes, {Mack N.} and Alvarez, {Ronald D.} and Peter Dall and Ramon Alemany and Curiel, {David T.} and Akseli Hemminki",

year = "2002",

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language = "English (US)",

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T1 - Treatment of ovarian cancer with a tropism modified oncolytic adenovirus

AU - Bauerschmitz, Gerd J.

AU - Lam, John T.

AU - Kanerva, Anna

AU - Suzuki, Kaori

AU - Nettelbeck, Dirk M.

AU - Dmitriev, Igor

AU - Krasnykh, Victor

AU - Mikheeva, Galina V.

AU - Barnes, Mack N.

AU - Alvarez, Ronald D.

AU - Dall, Peter

AU - Alemany, Ramon

AU - Curiel, David T.

AU - Hemminki, Akseli

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Ad5-Δ24RGD is an adenovirus that is selectively replication competent in cells defective in the Rb/p16 pathway, such as ovarian cancer cells. The fiber of Ad5-Δ24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of cancer cells. Oncolysis of cell lines was similar to that of a wild-type control, and replication in primary tumor material was shown using a novel three-dimensional spheroid model. Finally, an orthotopic murine model of peritoneally disseminated ovarian cancer was used to test i.p. administration to tumor-bearing animals. Injection of the agent resulted in eradication of i.p. disease, whereas control animals expired (P < 0.0001). These results suggest that Ad5-Δ24RGD could be useful for treatment of ovarian cancer in humans.

AB - Ad5-Δ24RGD is an adenovirus that is selectively replication competent in cells defective in the Rb/p16 pathway, such as ovarian cancer cells. The fiber of Ad5-Δ24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of cancer cells. Oncolysis of cell lines was similar to that of a wild-type control, and replication in primary tumor material was shown using a novel three-dimensional spheroid model. Finally, an orthotopic murine model of peritoneally disseminated ovarian cancer was used to test i.p. administration to tumor-bearing animals. Injection of the agent resulted in eradication of i.p. disease, whereas control animals expired (P < 0.0001). These results suggest that Ad5-Δ24RGD could be useful for treatment of ovarian cancer in humans.

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JO - Cancer Research

JF - Cancer Research

IS - 5

ER -

Treatment of ovarian cancer with a tropism modified oncolytic adenovirus

Abstract

ASJC Scopus subject areas

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