TY - JOUR
T1 - Treatment of refractory peripheral T-cell lymphoma with denileukin diftitox (ONTAK®)
AU - Talpur, Rakhshandra
AU - Apisarnthanarax, Narin
AU - Ward, Staci
AU - Duvic, Madeleine
N1 - Funding Information:
Funded in part by core grant to MDACC Comprehensive Cancer Center R21-CA74117.
PY - 2002
Y1 - 2002
N2 - Peripheral T-cell lymphomas (PTCLs) are an uncommon and heterogeneous group of well-differentiated, post-thymic T-cell malignancies that can present in the skin as cutaneous T-cell lymphomas. In general, their prognosis is poor, and specific therapy is not well defined. We report the successful treatment of a patient with relapsed, refractory PTCL who after failing 13 standard single and multiple chemotherapy regimens and experimental agents had a dramatic prolonged response to diftitoxin denileukin (ONTAK®). This fusion protein, composed of diphtheria toxin coupled to interleukin-2, is approved for cutaneous T-cell lymphomas, including mycosis fungoides, and should be considered for treatment of the rare subset of peripheral T-cell lymphomas.
AB - Peripheral T-cell lymphomas (PTCLs) are an uncommon and heterogeneous group of well-differentiated, post-thymic T-cell malignancies that can present in the skin as cutaneous T-cell lymphomas. In general, their prognosis is poor, and specific therapy is not well defined. We report the successful treatment of a patient with relapsed, refractory PTCL who after failing 13 standard single and multiple chemotherapy regimens and experimental agents had a dramatic prolonged response to diftitoxin denileukin (ONTAK®). This fusion protein, composed of diphtheria toxin coupled to interleukin-2, is approved for cutaneous T-cell lymphomas, including mycosis fungoides, and should be considered for treatment of the rare subset of peripheral T-cell lymphomas.
KW - Cutaneous T-cell lymphoma
KW - DAB-IL2
KW - Denileukin diftitox
KW - ONTAK®
KW - Peripheral T-cell lymphoma
KW - Serum soluble IL-2 receptor
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U2 - 10.1080/10428190210183
DO - 10.1080/10428190210183
M3 - Article
C2 - 11908715
AN - SCOPUS:0036123178
SN - 1042-8194
VL - 43
SP - 121
EP - 126
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -