Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab

Raymond Wong; Marcos De Lima; Daniel Couriel; Sergio Giralt; Chitra Hosing; Munir Shahjahan; Yee Chung Cheng; Jill Bruton; Richard Champlin; Issa Khouri

doi:10.1080/1042819031000067936

Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab

Raymond Wong, Marcos De Lima, Daniel Couriel, Sergio Giralt, Chitra Hosing, Munir Shahjahan, Yee Chung Cheng, Jill Bruton, Richard Champlin, Issa Khouri

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A 31-year-old man with a diffuse large-cell lymphoma in first refractory relapse received a bone marrow transplant (BMT) from a matched unrelated donor using CAMPATH-1H, carmustine, etoposide, cytarabine and melphalan as conditioning regimen, and methotrexate and tacrolimus for graft-versus-host disease (GVHD) prophylaxis. The transplant was complicated by grade II skin acute GVHD. Lymphoma relapse occurred 4 months post-transplant. Immunosuppression withdrawal plus rituximab induced a complete response. He remains in complete remission (CR) 11 months postimmunosuppression withdrawal and 15 months post-transplant.

Original language	English (US)
Pages (from-to)	829-832
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	44
Issue number	5
DOIs	https://doi.org/10.1080/1042819031000067936
State	Published - May 1 2003

Keywords

Graft-versus-lymphoma effect
Matched unrelated transplantation
Non-Hodgkin's lymphoma
Recurrence

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/1042819031000067936

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Wong, R., De Lima, M., Couriel, D., Giralt, S., Hosing, C., Shahjahan, M., Cheng, Y. C., Bruton, J., Champlin, R., & Khouri, I. (2003). Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab. Leukemia and Lymphoma, 44(5), 829-832. https://doi.org/10.1080/1042819031000067936

Wong, R, De Lima, M, Couriel, D, Giralt, S, Hosing, C, Shahjahan, M, Cheng, YC, Bruton, J, Champlin, R & Khouri, I 2003, 'Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab', Leukemia and Lymphoma, vol. 44, no. 5, pp. 829-832. https://doi.org/10.1080/1042819031000067936

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abstract = "A 31-year-old man with a diffuse large-cell lymphoma in first refractory relapse received a bone marrow transplant (BMT) from a matched unrelated donor using CAMPATH-1H, carmustine, etoposide, cytarabine and melphalan as conditioning regimen, and methotrexate and tacrolimus for graft-versus-host disease (GVHD) prophylaxis. The transplant was complicated by grade II skin acute GVHD. Lymphoma relapse occurred 4 months post-transplant. Immunosuppression withdrawal plus rituximab induced a complete response. He remains in complete remission (CR) 11 months postimmunosuppression withdrawal and 15 months post-transplant.",

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AU - Wong, Raymond

AU - De Lima, Marcos

AU - Couriel, Daniel

AU - Giralt, Sergio

AU - Hosing, Chitra

AU - Shahjahan, Munir

AU - Cheng, Yee Chung

AU - Bruton, Jill

AU - Champlin, Richard

AU - Khouri, Issa

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AB - A 31-year-old man with a diffuse large-cell lymphoma in first refractory relapse received a bone marrow transplant (BMT) from a matched unrelated donor using CAMPATH-1H, carmustine, etoposide, cytarabine and melphalan as conditioning regimen, and methotrexate and tacrolimus for graft-versus-host disease (GVHD) prophylaxis. The transplant was complicated by grade II skin acute GVHD. Lymphoma relapse occurred 4 months post-transplant. Immunosuppression withdrawal plus rituximab induced a complete response. He remains in complete remission (CR) 11 months postimmunosuppression withdrawal and 15 months post-transplant.

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KW - Non-Hodgkin's lymphoma

KW - Recurrence

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Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab

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