TY - JOUR
T1 - Treatment of the blastic phase of chronic myelogenous leukemia with mitoxantrone and high‐dose cytosine arabinoside
AU - Kantarjian, Hagop M.
AU - Walters, Ronald S.
AU - Keating, Michael J.
AU - Talpaz, Moshe
AU - Andersson, Borje
AU - Beran, Miloslav
AU - McCredie, Kenneth B.
AU - Freireich, Emil J.
PY - 1988/8/15
Y1 - 1988/8/15
N2 - Twenty‐seven patients in the blastic phase of chronic myelogenous leukemia received combination chemotherapy with mitoxantrone 5 mg/m2 intravenously daily for 5 days, and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. The patients' median age was 42 years (range, 19–61 years), and 26 of them had Philadelphia chromosome‐positive disease. Overall, seven patients (26%) achieved complete remission, and one (4%) had a partial remission for an overall response rate of 30%. Eight patients died during remission induction, and 11 had resistant disease. The median survival was 14 weeks for the total population, and 24 weeks for patients achieving a complete remission. The nonmyelosuppressive toxicity of the combination was acceptable; serious neurologic and pulmonary toxicities were uncommon. Significant marrow hypoplasia was observed resulting in a high incidence of febrile episodes (85% of patients). The combination of mitoxantrone and high‐dose cytosine arabinoside did not significantly improve overall prognosis. Since chemotherapy continues to produce disappointing results, other innovative approaches need to be explored.
AB - Twenty‐seven patients in the blastic phase of chronic myelogenous leukemia received combination chemotherapy with mitoxantrone 5 mg/m2 intravenously daily for 5 days, and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. The patients' median age was 42 years (range, 19–61 years), and 26 of them had Philadelphia chromosome‐positive disease. Overall, seven patients (26%) achieved complete remission, and one (4%) had a partial remission for an overall response rate of 30%. Eight patients died during remission induction, and 11 had resistant disease. The median survival was 14 weeks for the total population, and 24 weeks for patients achieving a complete remission. The nonmyelosuppressive toxicity of the combination was acceptable; serious neurologic and pulmonary toxicities were uncommon. Significant marrow hypoplasia was observed resulting in a high incidence of febrile episodes (85% of patients). The combination of mitoxantrone and high‐dose cytosine arabinoside did not significantly improve overall prognosis. Since chemotherapy continues to produce disappointing results, other innovative approaches need to be explored.
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U2 - 10.1002/1097-0142(19880815)62:4<672::AID-CNCR2820620404>3.0.CO;2-T
DO - 10.1002/1097-0142(19880815)62:4<672::AID-CNCR2820620404>3.0.CO;2-T
M3 - Article
C2 - 3165046
AN - SCOPUS:0023749506
SN - 0008-543X
VL - 62
SP - 672
EP - 676
JO - Cancer
JF - Cancer
IS - 4
ER -