TY - JOUR
T1 - Treatment of younger patients with chronic lymphocytic leukemia.
AU - Ferrajoli, Alessandra
PY - 2010
Y1 - 2010
N2 - Younger patients (defined as patients younger than 50-55 years of age) represent a small group of newly diagnosed patients with chronic lymphocytic leukemia, accounting only for 10% to 20% of newly diagnosed cases. However, once these patients become symptomatic and require treatment, their life expectancy is significantly reduced. Therapeutic approaches for younger patients should be directed at improving survival by achieving a complete remission and, where possible, eradicating minimal residual disease. Chemoimmunotherapy combinations carry the highest response rates and are commonly offered to younger patients. Additional strategies that should be considered for younger patients include early referral for stem-cell transplantation and clinical trials of consolidation therapy to eliminate minimal residual disease.
AB - Younger patients (defined as patients younger than 50-55 years of age) represent a small group of newly diagnosed patients with chronic lymphocytic leukemia, accounting only for 10% to 20% of newly diagnosed cases. However, once these patients become symptomatic and require treatment, their life expectancy is significantly reduced. Therapeutic approaches for younger patients should be directed at improving survival by achieving a complete remission and, where possible, eradicating minimal residual disease. Chemoimmunotherapy combinations carry the highest response rates and are commonly offered to younger patients. Additional strategies that should be considered for younger patients include early referral for stem-cell transplantation and clinical trials of consolidation therapy to eliminate minimal residual disease.
UR - http://www.scopus.com/inward/record.url?scp=79955039551&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955039551&partnerID=8YFLogxK
U2 - 10.1182/asheducation-2010.1.82
DO - 10.1182/asheducation-2010.1.82
M3 - Article
C2 - 21239775
AN - SCOPUS:79955039551
SN - 1520-4391
VL - 2010
SP - 82
EP - 89
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -