TY - JOUR
T1 - Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver
T2 - A Review
AU - Lillemoe, Heather A.
AU - Brudvik, Kristoffer W.
AU - Vauthey, Jean Nicolas
N1 - Publisher Copyright:
© 2019 by Thieme Medical Publishers, Inc.
PY - 2019
Y1 - 2019
N2 - Up to half of patients with a gastrointestinal stromal tumor (GIST) will present with metastatic disease, most commonly involving the liver. Prior to the introduction of tyrosine kinase inhibitors, treatment options were limited for patients with metastatic GIST to the liver resulting in dismal survival rates. However, with the advent of effective systemic chemotherapy and continued advancements in both surgical and local adjunctive therapy options, significant improvements in survival have been achieved. In this review, the authors characterize the evolution of the treatment approach for metastatic GIST to the liver, including the roles of both surgical resection and adjunctive therapies in today's practice.
AB - Up to half of patients with a gastrointestinal stromal tumor (GIST) will present with metastatic disease, most commonly involving the liver. Prior to the introduction of tyrosine kinase inhibitors, treatment options were limited for patients with metastatic GIST to the liver resulting in dismal survival rates. However, with the advent of effective systemic chemotherapy and continued advancements in both surgical and local adjunctive therapy options, significant improvements in survival have been achieved. In this review, the authors characterize the evolution of the treatment approach for metastatic GIST to the liver, including the roles of both surgical resection and adjunctive therapies in today's practice.
KW - GIST
KW - metastatic
KW - stromal tumors
UR - http://www.scopus.com/inward/record.url?scp=85070394132&partnerID=8YFLogxK
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U2 - 10.1055/s-0039-1685517
DO - 10.1055/s-0039-1685517
M3 - Review article
C2 - 31100757
AN - SCOPUS:85070394132
SN - 0272-8087
VL - 39
SP - 395
EP - 402
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
IS - 3
ER -