Abstract
Background Patients on clinical trials often experience declining quality of life (QOL). Little is known about the psychosocial variables that buffer against decline. Purpose This study aims to examine correlations between psychosocial variables and QOL over the course of a clinical trial in patients with metastatic renal cell cancer. Methods At baseline, 114 participants completed measures of treatment-related optimism, social support, and QOL (Functional Assessment of Cancer Therapy-General). QOL was also assessed 2, 4, and 8 weeks after the start of treatment with low-dose or intermediate-dose interferon. Results QOL decreased significantly in the intermediatedose group but not in the low-dose group (p<.01). The decline was less severe for patients who had high rather than low treatment optimism (p=.03). A higher level of social support was significantly associated with higher baseline QOL (p<.05) but a more rapid decline in QOL over time (p<.01). Conclusion Treatment optimism was favorably associated with QOL.
Original language | English (US) |
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Pages (from-to) | 313-320 |
Number of pages | 8 |
Journal | Annals of Behavioral Medicine |
Volume | 42 |
Issue number | 3 |
DOIs | |
State | Published - Dec 2011 |
Keywords
- Clinical trial
- Metastatic renal cell cancer
- Social support
- Treatment-related optimism
ASJC Scopus subject areas
- General Psychology
- Psychiatry and Mental health
MD Anderson CCSG core facilities
- Clinical Trials Office