Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses

Min Zhang; Yanping Yang; Ying Xu; Yaqing Qie; Jiuling Wang; Bingdong Zhu; Qingzhong Wang; Ruiliang Jin; Shengfeng Xu; Honghai Wang

doi:10.1111/j.1574-695X.2006.00174.x

Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses

Min Zhang, Yanping Yang, Ying Xu, Yaqing Qie, Jiuling Wang, Bingdong Zhu, Qingzhong Wang, Ruiliang Jin, Shengfeng Xu, Honghai Wang

Genetics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-γ in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.

Original language	English (US)
Pages (from-to)	68-74
Number of pages	7
Journal	FEMS Immunology and Medical Microbiology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-695X.2006.00174.x
State	Published - Feb 2007

Keywords

Bacillus Calmette-Guérin (BCG)
Mycobacterium tuberculosis
Trehalose-6-phosphate phosphatase

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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title = "Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses",

abstract = "Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Gu{\'e}rin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-γ in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.",

keywords = "Bacillus Calmette-Gu{\'e}rin (BCG), Mycobacterium tuberculosis, Trehalose-6-phosphate phosphatase",

author = "Min Zhang and Yanping Yang and Ying Xu and Yaqing Qie and Jiuling Wang and Bingdong Zhu and Qingzhong Wang and Ruiliang Jin and Shengfeng Xu and Honghai Wang",

year = "2007",

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T1 - Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses

AU - Zhang, Min

AU - Yang, Yanping

AU - Xu, Ying

AU - Qie, Yaqing

AU - Wang, Jiuling

AU - Zhu, Bingdong

AU - Wang, Qingzhong

AU - Jin, Ruiliang

AU - Xu, Shengfeng

AU - Wang, Honghai

PY - 2007/2

Y1 - 2007/2

N2 - Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-γ in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.

AB - Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-γ in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.

KW - Bacillus Calmette-Guérin (BCG)

KW - Mycobacterium tuberculosis

KW - Trehalose-6-phosphate phosphatase

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Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses

Abstract

Keywords

ASJC Scopus subject areas

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