Trehalose Maintains Bioactivity and Promotes Sustained Release of BMP-2 from Lyophilized CDHA Scaffolds for Enhanced Osteogenesis In Vitro and In Vivo

Agriculture & Biology

• bone morphogenetic proteins 100%
• bone formation 84%
• hydroxyapatite 80%
• trehalose 77%
• calcium 45%
• calcium phosphates 25%
• bones 24%
• mesenchymal stromal cells 18%
• freeze drying 15%
• growth factors 13%
• preserves 13%
• fluorescent labeling 10%
• alizarin 9%
• micro-computed tomography 9%
• tissue engineering 8%
• fluorescent dyes 7%
• alkaline phosphatase 6%
• adsorption 6%
• inactivation 5%
• enzyme-linked immunosorbent assay 5%
• quantitative polymerase chain reaction 5%
• minerals 5%
• rats 3%
• testing 2%
• proteins 2%

Medicine & Life Sciences

• Trehalose 98%
• Bone Morphogenetic Protein 2 91%
• Durapatite 76%
• Osteogenesis 63%
• In Vitro Techniques 31%
• calcium phosphate 23%
• Freeze Drying 18%
• Mesenchymal Stem Cells 12%
• Bone and Bones 12%
• Intercellular Signaling Peptides and Proteins 11%
• Alizarin Red S 10%
• fluorexon 10%
• Bone Regeneration 8%
• Adsorption 7%
• Fluorescent Dyes 7%
• Tissue Engineering 7%
• Minerals 7%
• Alkaline Phosphatase 6%
• Real-Time Polymerase Chain Reaction 5%
• Enzyme-Linked Immunosorbent Assay 5%
• Tomography 4%
• Staining and Labeling 4%
• Proteins 2%

Chemistry

• Trehalose 90%
• Bioactivity 51%
• Calcium Phosphate 32%
• Alizarin Red S 14%
• Calcein 14%
• Fluorochrome 13%
• Osteogenic 13%
• Mineral 8%
• Volume 5%
• Adsorption 5%
• Protein 4%