TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora; Ekaterina Esaulova; William Vermi; Jinchao Hou; Yun Chen; Jingqin Luo; Simone Brioschi; Mattia Bugatti; Andrea Salvatore Omodei; Biancamaria Ricci; Catrina Fronick; Santosh K. Panda; Yoshiko Takeuchi; Matthew M. Gubin; Roberta Faccio; Marina Cella; Susan Gilfillan; Emil R. Unanue; Maxim N. Artyomov; Robert D. Schreiber; Marco Colonna

doi:10.1016/j.cell.2020.07.013

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora, Ekaterina Esaulova, William Vermi, Jinchao Hou, Yun Chen, Jingqin Luo, Simone Brioschi, Mattia Bugatti, Andrea Salvatore Omodei, Biancamaria Ricci, Catrina Fronick, Santosh K. Panda, Yoshiko Takeuchi, Matthew M. Gubin, Roberta Faccio, Marina Cella, Susan Gilfillan, Emil R. Unanue, Maxim N. Artyomov, Robert D. SchreiberMarco Colonna

Immunology

Research output: Contribution to journal › Article › peer-review

269 Scopus citations

Abstract

TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

Original language	English (US)
Pages (from-to)	886-900.e17
Journal	Cell
Volume	182
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2020.07.013
State	Published - Aug 20 2020

Keywords

TREM2
breast cancer
checkpoint blockade
colorectal cancer
human
macrophages
sarcoma
tumor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.07.013

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Molgora, M., Esaulova, E., Vermi, W., Hou, J., Chen, Y., Luo, J., Brioschi, S., Bugatti, M., Omodei, A. S., Ricci, B., Fronick, C., Panda, S. K., Takeuchi, Y., Gubin, M. M., Faccio, R., Cella, M., Gilfillan, S., Unanue, E. R., Artyomov, M. N., ... Colonna, M. (2020). TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell, 182(4), 886-900.e17. https://doi.org/10.1016/j.cell.2020.07.013

Molgora, M, Esaulova, E, Vermi, W, Hou, J, Chen, Y, Luo, J, Brioschi, S, Bugatti, M, Omodei, AS, Ricci, B, Fronick, C, Panda, SK, Takeuchi, Y, Gubin, MM, Faccio, R, Cella, M, Gilfillan, S, Unanue, ER, Artyomov, MN, Schreiber, RD & Colonna, M 2020, 'TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy', Cell, vol. 182, no. 4, pp. 886-900.e17. https://doi.org/10.1016/j.cell.2020.07.013

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title = "TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy",

abstract = "TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.",

keywords = "TREM2, breast cancer, checkpoint blockade, colorectal cancer, human, macrophages, sarcoma, tumor",

author = "Martina Molgora and Ekaterina Esaulova and William Vermi and Jinchao Hou and Yun Chen and Jingqin Luo and Simone Brioschi and Mattia Bugatti and Omodei, {Andrea Salvatore} and Biancamaria Ricci and Catrina Fronick and Panda, {Santosh K.} and Yoshiko Takeuchi and Gubin, {Matthew M.} and Roberta Faccio and Marina Cella and Susan Gilfillan and Unanue, {Emil R.} and Artyomov, {Maxim N.} and Schreiber, {Robert D.} and Marco Colonna",

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AU - Molgora, Martina

AU - Esaulova, Ekaterina

AU - Vermi, William

AU - Hou, Jinchao

AU - Chen, Yun

AU - Luo, Jingqin

AU - Brioschi, Simone

AU - Bugatti, Mattia

AU - Omodei, Andrea Salvatore

AU - Ricci, Biancamaria

AU - Fronick, Catrina

AU - Panda, Santosh K.

AU - Takeuchi, Yoshiko

AU - Gubin, Matthew M.

AU - Faccio, Roberta

AU - Cella, Marina

AU - Gilfillan, Susan

AU - Unanue, Emil R.

AU - Artyomov, Maxim N.

AU - Schreiber, Robert D.

AU - Colonna, Marco

PY - 2020/8/20

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KW - checkpoint blockade

KW - colorectal cancer

KW - human

KW - macrophages

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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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