Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease

A. W. Lemstra; L. Verhagen Metman; J. I. Lee; P. M. Dougherty; F. A. Lenz

doi:10.1016/S0304-3940(99)00343-2

Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease

A. W. Lemstra, L. Verhagen Metman, J. I. Lee, P. M. Dougherty, F. A. Lenz

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Neurons in the internal segment of the globus pallidus (GPi) oscillate at approximately the frequency of parkinsonian tremor. However, the correlation of that activity with tremor has not previously been studied. We now describe the relationship between single neuron activity in the arm sensorimotor portion of GPi and upper extremity tremor in patients with Parkinson's disease. There was a significant concentration of power in the tremor-frequency range (3-6 Hz) for 11/44 GPi neurons. However, pallidal tremor-frequency activity correlated significantly with electromyogram (EMG) activity during tremor for only a single GPi neuron. These data are most consistent with the hypothesis that the output of neurons in GPi is transformed in thalamus by a non-linear mechanism, before transmission via the cortex to the spinal motorneurons that drive movement.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Neuroscience Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00343-2
State	Published - May 28 1999
Externally published	Yes

Keywords

Central pattern generator
Globus pallidus
Neurophysiology
Parkinson's disease
Tremor
Tremor-related activity

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(99)00343-2

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title = "Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease",

abstract = "Neurons in the internal segment of the globus pallidus (GPi) oscillate at approximately the frequency of parkinsonian tremor. However, the correlation of that activity with tremor has not previously been studied. We now describe the relationship between single neuron activity in the arm sensorimotor portion of GPi and upper extremity tremor in patients with Parkinson's disease. There was a significant concentration of power in the tremor-frequency range (3-6 Hz) for 11/44 GPi neurons. However, pallidal tremor-frequency activity correlated significantly with electromyogram (EMG) activity during tremor for only a single GPi neuron. These data are most consistent with the hypothesis that the output of neurons in GPi is transformed in thalamus by a non-linear mechanism, before transmission via the cortex to the spinal motorneurons that drive movement.",

keywords = "Central pattern generator, Globus pallidus, Neurophysiology, Parkinson's disease, Tremor, Tremor-related activity",

author = "Lemstra, {A. W.} and {Verhagen Metman}, L. and Lee, {J. I.} and Dougherty, {P. M.} and Lenz, {F. A.}",

note = "Funding Information: This work was supported by grants to F.A.L. from the Eli Lilly Corporation and the NIH (NS28598, K08 NS01384, P01 NS32386-Project 1). We thank Lance Rowland for excellent technical assistance.",

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doi = "10.1016/S0304-3940(99)00343-2",

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AU - Lemstra, A. W.

AU - Verhagen Metman, L.

AU - Lee, J. I.

AU - Dougherty, P. M.

AU - Lenz, F. A.

N1 - Funding Information: This work was supported by grants to F.A.L. from the Eli Lilly Corporation and the NIH (NS28598, K08 NS01384, P01 NS32386-Project 1). We thank Lance Rowland for excellent technical assistance.

PY - 1999/5/28

Y1 - 1999/5/28

N2 - Neurons in the internal segment of the globus pallidus (GPi) oscillate at approximately the frequency of parkinsonian tremor. However, the correlation of that activity with tremor has not previously been studied. We now describe the relationship between single neuron activity in the arm sensorimotor portion of GPi and upper extremity tremor in patients with Parkinson's disease. There was a significant concentration of power in the tremor-frequency range (3-6 Hz) for 11/44 GPi neurons. However, pallidal tremor-frequency activity correlated significantly with electromyogram (EMG) activity during tremor for only a single GPi neuron. These data are most consistent with the hypothesis that the output of neurons in GPi is transformed in thalamus by a non-linear mechanism, before transmission via the cortex to the spinal motorneurons that drive movement.

AB - Neurons in the internal segment of the globus pallidus (GPi) oscillate at approximately the frequency of parkinsonian tremor. However, the correlation of that activity with tremor has not previously been studied. We now describe the relationship between single neuron activity in the arm sensorimotor portion of GPi and upper extremity tremor in patients with Parkinson's disease. There was a significant concentration of power in the tremor-frequency range (3-6 Hz) for 11/44 GPi neurons. However, pallidal tremor-frequency activity correlated significantly with electromyogram (EMG) activity during tremor for only a single GPi neuron. These data are most consistent with the hypothesis that the output of neurons in GPi is transformed in thalamus by a non-linear mechanism, before transmission via the cortex to the spinal motorneurons that drive movement.

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KW - Neurophysiology

KW - Parkinson's disease

KW - Tremor

KW - Tremor-related activity

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Tremor-frequency (3-6 Hz) activity in the sensorimotor arm representation of the internal segment of the globus pallidus in patients with Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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