TY - JOUR
T1 - Trichosporonosis in a tertiary care cancer center
T2 - Risk factors, changing spectrum and determinants of outcome
AU - Kontoyiannis, Dimitrios P.
AU - Torres, Harrys A.
AU - Chagua, Marlon
AU - Hachem, Ray
AU - Tarrand, Jeffrey J.
AU - Bodey, Gerald P.
AU - Raad, Issam I.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - To assess the spectrum and outcome of trichosporonosis (TS) in cancer patients, we reviewed the medical records of 17 such patients with TS. TS presented most commonly as fungemia (n = 10, including 7 with central-venous-catheter-related infection) and either pulmonary or soft tissue infection (n = 3, each). Most patients (65%) had acute leukemia, 11 (65%) had neutropenia, and 9 (53%) had received high doses of corticosteroids. 10 patients had breakthrough TS during therapy with at least 1 of the following: amphotericin B, fluconazole, itraconazole, and voriconazole. The 30-d crude mortality rate was 53%. Predictors of mortality by using univariate analysis included: high median APACHE II score (p <0.01), use of high dose of corticosteroids (p = 0.01), and admission to the intensive care unit (p <0.01). TS is associated with a high mortality rate in cancer patients. The spectrum of infection at our institution has shifted from a predominance of disseminated infection to CVC-related fungemias without evidence of tissue invasion.
AB - To assess the spectrum and outcome of trichosporonosis (TS) in cancer patients, we reviewed the medical records of 17 such patients with TS. TS presented most commonly as fungemia (n = 10, including 7 with central-venous-catheter-related infection) and either pulmonary or soft tissue infection (n = 3, each). Most patients (65%) had acute leukemia, 11 (65%) had neutropenia, and 9 (53%) had received high doses of corticosteroids. 10 patients had breakthrough TS during therapy with at least 1 of the following: amphotericin B, fluconazole, itraconazole, and voriconazole. The 30-d crude mortality rate was 53%. Predictors of mortality by using univariate analysis included: high median APACHE II score (p <0.01), use of high dose of corticosteroids (p = 0.01), and admission to the intensive care unit (p <0.01). TS is associated with a high mortality rate in cancer patients. The spectrum of infection at our institution has shifted from a predominance of disseminated infection to CVC-related fungemias without evidence of tissue invasion.
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U2 - 10.1080/00365540410017563
DO - 10.1080/00365540410017563
M3 - Article
C2 - 15370667
AN - SCOPUS:4544364560
SN - 0036-5548
VL - 36
SP - 564
EP - 569
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 8
ER -