Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features

H. U. Shimin; Robert E. Mrak; Peter J. Goldblatt

Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features

H. U. Shimin, Robert E. Mrak, Peter J. Goldblatt

Research output: Contribution to journal › Article › peer-review

Abstract

We report an unusual case of hepatocellular carcinoma with three histologically and immunohistochemically distinct components, arising in a noncirrhotic liver, with a pulmonary tumor embolus from one of the three components. The histological patterns of the three components were fibrolamellar, well-differentiated nodular, and pleomorphic. The immunophenotypes were, respectively CK7^- /CK20^- /Hep Par¹+, CK7⁺ /CK20^- /Hep Par1⁺ and CK7⁺ /CK20⁺ /Hep Par1^-. The tumor in the pulmonary embolus showed only the morphological and immunohistochemical features of the pleomorphic component. This unusual case of metastasizing hepatocellular carcinoma with three distinct histologic components suggests that the histological and immunophenotype of the tumor might be useful in predicting metastatic potential.

Original language	English (US)
Pages (from-to)	79-83
Number of pages	5
Journal	Connecticut Medicine
Volume	74
Issue number	2
State	Published - Feb 2010
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features",

abstract = "We report an unusual case of hepatocellular carcinoma with three histologically and immunohistochemically distinct components, arising in a noncirrhotic liver, with a pulmonary tumor embolus from one of the three components. The histological patterns of the three components were fibrolamellar, well-differentiated nodular, and pleomorphic. The immunophenotypes were, respectively CK7- /CK20- /Hep Par1+, CK7+ /CK20- /Hep Par1+ and CK7+ /CK20+ /Hep Par1-. The tumor in the pulmonary embolus showed only the morphological and immunohistochemical features of the pleomorphic component. This unusual case of metastasizing hepatocellular carcinoma with three distinct histologic components suggests that the histological and immunophenotype of the tumor might be useful in predicting metastatic potential.",

author = "Shimin, {H. U.} and Mrak, {Robert E.} and Goldblatt, {Peter J.}",

year = "2010",

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T1 - Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features

AU - Shimin, H. U.

AU - Mrak, Robert E.

AU - Goldblatt, Peter J.

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N2 - We report an unusual case of hepatocellular carcinoma with three histologically and immunohistochemically distinct components, arising in a noncirrhotic liver, with a pulmonary tumor embolus from one of the three components. The histological patterns of the three components were fibrolamellar, well-differentiated nodular, and pleomorphic. The immunophenotypes were, respectively CK7- /CK20- /Hep Par1+, CK7+ /CK20- /Hep Par1+ and CK7+ /CK20+ /Hep Par1-. The tumor in the pulmonary embolus showed only the morphological and immunohistochemical features of the pleomorphic component. This unusual case of metastasizing hepatocellular carcinoma with three distinct histologic components suggests that the histological and immunophenotype of the tumor might be useful in predicting metastatic potential.

AB - We report an unusual case of hepatocellular carcinoma with three histologically and immunohistochemically distinct components, arising in a noncirrhotic liver, with a pulmonary tumor embolus from one of the three components. The histological patterns of the three components were fibrolamellar, well-differentiated nodular, and pleomorphic. The immunophenotypes were, respectively CK7- /CK20- /Hep Par1+, CK7+ /CK20- /Hep Par1+ and CK7+ /CK20+ /Hep Par1-. The tumor in the pulmonary embolus showed only the morphological and immunohistochemical features of the pleomorphic component. This unusual case of metastasizing hepatocellular carcinoma with three distinct histologic components suggests that the histological and immunophenotype of the tumor might be useful in predicting metastatic potential.

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ER -

Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features

Abstract

ASJC Scopus subject areas

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