TY - JOUR
T1 - Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway
AU - Yanchun, Ma
AU - Yi, Wang
AU - Lu, Wang
AU - Yu, Qian
AU - Jian, Yang
AU - Pengzhou, Kong
AU - Ting, Yan
AU - Hongyi, Li
AU - Fang, Wang
AU - Xiaolong, Cheng
AU - Yongping, Cui
N1 - Publisher Copyright:
© 2019
PY - 2019/5/15
Y1 - 2019/5/15
N2 - Triptolide, the component of traditional Chinese herb, has been used as an inflammatory medicine and reported to be anti-tumor for various cancers recently. However, the effect of triptolide on Esophageal Squamous Cell Cancer (ESCC) has not yet been elucidated. In the study, we found that triptolide significantly inhibited cell proliferation, invasion, migration and survivability of ESCC cells. Moreover, we observed that triptolide induced ESCC cell cycle arrest at the G1/S phase and apoptosis through cyclin D1-CDK4/6 regulation and caspases activation. In addition, we revealed that triptolide regulates cell apoptosis and metastasis by p53 and mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, respectively. Meanwhile, the inhibitory effect of triptolide on ESCC was validated in mouse xenograft model. So, we propose that triptolide may be a candidate drug for ESCC.
AB - Triptolide, the component of traditional Chinese herb, has been used as an inflammatory medicine and reported to be anti-tumor for various cancers recently. However, the effect of triptolide on Esophageal Squamous Cell Cancer (ESCC) has not yet been elucidated. In the study, we found that triptolide significantly inhibited cell proliferation, invasion, migration and survivability of ESCC cells. Moreover, we observed that triptolide induced ESCC cell cycle arrest at the G1/S phase and apoptosis through cyclin D1-CDK4/6 regulation and caspases activation. In addition, we revealed that triptolide regulates cell apoptosis and metastasis by p53 and mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, respectively. Meanwhile, the inhibitory effect of triptolide on ESCC was validated in mouse xenograft model. So, we propose that triptolide may be a candidate drug for ESCC.
KW - ESCC
KW - MAPK/ERK pathway
KW - Metastasis
KW - Proliferation
KW - Triptolide
UR - http://www.scopus.com/inward/record.url?scp=85062146421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062146421&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2019.02.030
DO - 10.1016/j.ejphar.2019.02.030
M3 - Article
C2 - 30779917
AN - SCOPUS:85062146421
SN - 0014-2999
VL - 851
SP - 43
EP - 51
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
ER -