TY - JOUR
T1 - Trisomy 14 as a sole chromosome abnormality is associated with older age, a heterogenous group of myeloid neoplasms with dysplasia, and a wide spectrum of disease progression
AU - Cui, Wei
AU - Bueso-Ramos, Carlos E.
AU - Yin, C. Cameron
AU - Sun, Jianlan
AU - Chen, Su
AU - Muddasani, Ramya
AU - Lu, Gary
PY - 2010
Y1 - 2010
N2 - Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described. We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14. Our results show that cases with isolated trisomy 14 encompass a heterogenous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44), myelodysplastic/myeloproliferative neoplasms (31), and acute myeloid leukemia (25). The patients are usually elder (median age 71 years), and there is a male predominance (82). Multilineage dysplasia is noted in all cases. Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur. Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.
AB - Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described. We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14. Our results show that cases with isolated trisomy 14 encompass a heterogenous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44), myelodysplastic/myeloproliferative neoplasms (31), and acute myeloid leukemia (25). The patients are usually elder (median age 71 years), and there is a male predominance (82). Multilineage dysplasia is noted in all cases. Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur. Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.
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U2 - 10.1155/2010/365318
DO - 10.1155/2010/365318
M3 - Article
C2 - 21331167
AN - SCOPUS:79952206463
SN - 1110-7243
VL - 2010
JO - Journal of Biomedicine and Biotechnology
JF - Journal of Biomedicine and Biotechnology
M1 - 365318
ER -