Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland

Adel K. El-Naggar; Mercedes Lovell; Ann Killary; John G. Batsakis

doi:10.1016/0165-4608(94)90456-1

Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland

Adel K. El-Naggar, Mercedes Lovell, Ann Killary, John G. Batsakis

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Abstract

We describe the cytogenetic findings in a moderately differentiated primary mucoepidermoid carcinoma of the base of the tongue. The only karyotypic abnormality found in the primary culture of this neoplasm was trisomy 5. This finding is remarkably different from previous cytogenetic studies of mucoepidermoid carcinomas, which have shown heterogeneous and unrelated chromosomal aberrations. Our results suggest that trisomy 5 may be an early aberration in the development of this neoplasm.

Original language	English (US)
Pages (from-to)	96-99
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(94)90456-1
State	Published - Sep 1994

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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abstract = "We describe the cytogenetic findings in a moderately differentiated primary mucoepidermoid carcinoma of the base of the tongue. The only karyotypic abnormality found in the primary culture of this neoplasm was trisomy 5. This finding is remarkably different from previous cytogenetic studies of mucoepidermoid carcinomas, which have shown heterogeneous and unrelated chromosomal aberrations. Our results suggest that trisomy 5 may be an early aberration in the development of this neoplasm.",

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AU - Killary, Ann

AU - Batsakis, John G.

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AB - We describe the cytogenetic findings in a moderately differentiated primary mucoepidermoid carcinoma of the base of the tongue. The only karyotypic abnormality found in the primary culture of this neoplasm was trisomy 5. This finding is remarkably different from previous cytogenetic studies of mucoepidermoid carcinomas, which have shown heterogeneous and unrelated chromosomal aberrations. Our results suggest that trisomy 5 may be an early aberration in the development of this neoplasm.

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Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland

Abstract

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