TY - JOUR
T1 - Tumor cell-derived exosomes
T2 - A message in a bottle
AU - Kharaziha, Pedram
AU - Ceder, Sophia
AU - Li, Qiao
AU - Panaretakis, Theocharis
N1 - Funding Information:
TP is supported by Cancerfonden, Vetenskapsrådet Cancerföreningen, Åke Wiberg stiftelse and Svenska Läkaresällskapet. PK is supported by Karolinska Institutet funds for doctoral students (KID).
PY - 2012/8
Y1 - 2012/8
N2 - Exosomes constitute the newest mode of intercellular communication, transmitting information between cells. This exchange of molecular information is facilitated by their unique composition which is enriched with enzymes, structural proteins, adhesion molecules, lipid rafts and RNAs. Following the discovery that cancer cells secrete excessive amounts of exosomes compared to normal cells, it became evident that i) these vesicles can be used as diagnostic markers; ii) their active secretion has functional implications, albeit unknown whether they are tumor promoting or suppressing. Notably, the interplay via the exchange of exosomes between cancer cells and between cancer cells and the tumor stroma may promote the transfer of oncogenes (e.g. β-catenin, CEA, HER2, Melan-A/Mart-1 and LMP-1) and onco-microRNAs (e.g. let7, miR1, miR15, miR16 and miR375) from one cell to another, leading to the reprogramming of the recipient cells. The molecular composition and functional role of tumor cell-derived exosomes in tumorigenesis, metastasis and response to therapy are slowly decrypted and the latest findings as well as potential therapeutic strategies are discussed in this review.
AB - Exosomes constitute the newest mode of intercellular communication, transmitting information between cells. This exchange of molecular information is facilitated by their unique composition which is enriched with enzymes, structural proteins, adhesion molecules, lipid rafts and RNAs. Following the discovery that cancer cells secrete excessive amounts of exosomes compared to normal cells, it became evident that i) these vesicles can be used as diagnostic markers; ii) their active secretion has functional implications, albeit unknown whether they are tumor promoting or suppressing. Notably, the interplay via the exchange of exosomes between cancer cells and between cancer cells and the tumor stroma may promote the transfer of oncogenes (e.g. β-catenin, CEA, HER2, Melan-A/Mart-1 and LMP-1) and onco-microRNAs (e.g. let7, miR1, miR15, miR16 and miR375) from one cell to another, leading to the reprogramming of the recipient cells. The molecular composition and functional role of tumor cell-derived exosomes in tumorigenesis, metastasis and response to therapy are slowly decrypted and the latest findings as well as potential therapeutic strategies are discussed in this review.
KW - Cancer therapy
KW - Exosomes
KW - Metastatic niche
KW - Microenvironment
KW - Molecular profile
KW - Multivesicular bodies
UR - http://www.scopus.com/inward/record.url?scp=84859927971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859927971&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2012.03.006
DO - 10.1016/j.bbcan.2012.03.006
M3 - Review article
C2 - 22503823
AN - SCOPUS:84859927971
SN - 0304-419X
VL - 1826
SP - 103
EP - 111
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
ER -