Abstract
Tumor-resident microbes (TRM) are an integral component of the tumor microenvironment (TME). TRM can influence tumor growth, distant dissemination, and response to therapies by interfering with molecular pathways in tumor cells as well as with other components of the TME. Novel technologies are improving the identification and visualization of cell type-specific microbes in the TME. The mechanisms that mediate the role of TRM at the primary tumors and metastatic sites are being elucidated. This knowledge is providing novel perspectives for targeting microbes or using microbial interventions for cancer interception or therapy.
Original language | English (US) |
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Pages (from-to) | 347-355 |
Number of pages | 9 |
Journal | Trends in Cancer |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2024 |
Keywords
- cancer
- immunity
- metastasis
- microenvironment
- tumor-resident microbes
- tumorigenesis
ASJC Scopus subject areas
- Oncology
- Cancer Research