TY - JOUR
T1 - Tumor stroma as targets for cancer therapy
AU - Zhang, Jing
AU - Liu, Jinsong
N1 - Funding Information:
The authors thank for MD Anderson Cancer Center's Department of Scientific Publication for insightful manuscript editing and revision and Xueqin Cai for preparing our figures. J.L. was supported by an R01 grant ( R01CA131183-01A2 ) and ovarian cancer Specialized Programs of Research Excellence (SPORE) grant ( IP50CA83638 ) from the National Institutes of Health and Ovarian Cancer Research Fund . This work was also supported, in part, by the National Institutes of Health through MD Anderson's Cancer Center Support Grant ( CA016672 ). J. Zhang was a visiting faculty at MD Anderson Cancer Center and was supported by National Natural Science Foundation of China ( NSFC 81070582 ).
PY - 2013/2
Y1 - 2013/2
N2 - Cancer is not only composed malignant epithelial component but also stromal components such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor microenvironment (TME) is formed to promote tumorigenesis, progression, and metastasis. As the most abundant component in the TME, cancer-associated fibroblasts (CAFs) are involved in multifaceted mechanistic details including remodeling the extracellular matrix, suppressing immune responses, and secreting growth factors and cytokines that mediate signaling pathways to extensively affect tumor cell growth and invasiveness, differentiation, angiogenesis, and chronic inflammatory milieu. Today, more and more therapeutic strategies are purposefully designed to target the TME as well as tumor cells. This review will focus on the role of CAFs in tumor development and the novel strategies to target this component to inhibit the tumor growth.
AB - Cancer is not only composed malignant epithelial component but also stromal components such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor microenvironment (TME) is formed to promote tumorigenesis, progression, and metastasis. As the most abundant component in the TME, cancer-associated fibroblasts (CAFs) are involved in multifaceted mechanistic details including remodeling the extracellular matrix, suppressing immune responses, and secreting growth factors and cytokines that mediate signaling pathways to extensively affect tumor cell growth and invasiveness, differentiation, angiogenesis, and chronic inflammatory milieu. Today, more and more therapeutic strategies are purposefully designed to target the TME as well as tumor cells. This review will focus on the role of CAFs in tumor development and the novel strategies to target this component to inhibit the tumor growth.
KW - Cancer signaling
KW - Cancer therapy
KW - Cancer-associated fibroblasts
KW - Extracellular matrix
KW - Tumor microenvironment
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U2 - 10.1016/j.pharmthera.2012.10.003
DO - 10.1016/j.pharmthera.2012.10.003
M3 - Review article
C2 - 23064233
AN - SCOPUS:84872785096
SN - 0163-7258
VL - 137
SP - 200
EP - 215
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 2
ER -