TY - JOUR
T1 - Tumor variation in the cancer family syndrome
T2 - Ovarian cancer
AU - Lynch, Henry T.
AU - Lynch, Patrick M.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1979/9
Y1 - 1979/9
N2 - The Cancer Family Syndrome is a hereditary disorder (autosomal dominant), characterized by early onset cancer of the colon (particularly the proximal colon) and endometrium, with an excess of multiple primary cancers. Recent evidence reflects the possibility of an even broader tumor spectrum consisting of carcinoma of the stomach, the ovary, the kidney, and possibly other organs. A family with the cardinal features of the Cancer Family Syndrome is described, including two sisters and their mother who had ovarian carcinoma at early ages (38, 46, and 49 years). Two of these three women have shown unusual tolerance to cancer, despite invasion of the primary tumors. Implications for cancer surveillance and management are discussed.
AB - The Cancer Family Syndrome is a hereditary disorder (autosomal dominant), characterized by early onset cancer of the colon (particularly the proximal colon) and endometrium, with an excess of multiple primary cancers. Recent evidence reflects the possibility of an even broader tumor spectrum consisting of carcinoma of the stomach, the ovary, the kidney, and possibly other organs. A family with the cardinal features of the Cancer Family Syndrome is described, including two sisters and their mother who had ovarian carcinoma at early ages (38, 46, and 49 years). Two of these three women have shown unusual tolerance to cancer, despite invasion of the primary tumors. Implications for cancer surveillance and management are discussed.
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U2 - 10.1016/0002-9610(79)90280-0
DO - 10.1016/0002-9610(79)90280-0
M3 - Article
C2 - 474881
AN - SCOPUS:0018719243
SN - 0002-9610
VL - 138
SP - 439
EP - 442
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 3
ER -