Twenty-three novel HLA-B alleles identified during intermediate-resolution testing

A. M. Lazaro; K. Cao; C. Masaberg; N. K. Steiner; Y. Xiao; B. Tu; V. Turner; P. Nickerson; S. Stoll; C. Schall; R. Valdez; J. Ng; R. J. Hartzman; C. K. Hurley

doi:10.1111/j.1399-0039.2006.00661.x

Twenty-three novel HLA-B alleles identified during intermediate-resolution testing

A. M. Lazaro, K. Cao, C. Masaberg, N. K. Steiner, Y. Xiao, B. Tu, V. Turner, P. Nickerson, S. Stoll, C. Schall, R. Valdez, J. Ng, R. J. Hartzman, C. K. Hurley

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Tissue Antigens
Volume	68
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-0039.2006.00661.x
State	Published - Sep 2006
Externally published	Yes

Keywords

DNA sequencing
HLA-B

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.2006.00661.x

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title = "Twenty-three novel HLA-B alleles identified during intermediate-resolution testing",

abstract = "Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.",

keywords = "DNA sequencing, HLA-B",

author = "Lazaro, {A. M.} and K. Cao and C. Masaberg and Steiner, {N. K.} and Y. Xiao and B. Tu and V. Turner and P. Nickerson and S. Stoll and C. Schall and R. Valdez and J. Ng and Hartzman, {R. J.} and Hurley, {C. K.}",

year = "2006",

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doi = "10.1111/j.1399-0039.2006.00661.x",

language = "English (US)",

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T1 - Twenty-three novel HLA-B alleles identified during intermediate-resolution testing

AU - Lazaro, A. M.

AU - Cao, K.

AU - Masaberg, C.

AU - Steiner, N. K.

AU - Xiao, Y.

AU - Tu, B.

AU - Turner, V.

AU - Nickerson, P.

AU - Stoll, S.

AU - Schall, C.

AU - Valdez, R.

AU - Ng, J.

AU - Hartzman, R. J.

AU - Hurley, C. K.

PY - 2006/9

Y1 - 2006/9

N2 - Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.

AB - Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.

KW - DNA sequencing

KW - HLA-B

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Twenty-three novel HLA-B alleles identified during intermediate-resolution testing

Abstract

Keywords

ASJC Scopus subject areas

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