Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer

Marisa J.L. Aitken; Christopher B. Benton; Ghayas C. Issa; Koji Sasaki; Musa Yilmaz; Nicholas J. Short

doi:10.1159/000513925

Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer

Marisa J.L. Aitken, Christopher B. Benton, Ghayas C. Issa, Koji Sasaki, Musa Yilmaz, Nicholas J. Short

Leukemia

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

CML is defined by the presence of an oncogenic fusion protein caused by a reciprocal translocation between chromosomes 9q and 22q. While our molecular understanding of CML pathogenesis has revolutionized drug development for this disease, we have yet to identify many predisposing factors for CML. Familial occurrence of CML has been rarely reported. Here, we describe 2 cases of CML in a 24-year-old woman and in her 73-year-old maternal great aunt. We describe genetic variants in these patients and report on their environmental exposures that may have contributed to CML pathogenesis. The possible familial association of these 2 cases of CML warrants further investigation into more definitive etiologies of this disease.

Original language	English (US)
Pages (from-to)	585-590
Number of pages	6
Journal	Acta haematologica
Volume	144
Issue number	5
DOIs	https://doi.org/10.1159/000513925
State	Published - Sep 1 2021

Keywords

Chronic myeloid leukemia
Familial cancer
Hereditary cancer syndromes

ASJC Scopus subject areas

Hematology

MD Anderson CCSG core facilities

Clinical Trials Office

Access to Document

10.1159/000513925

Cite this

@article{383795c47fa3430eb36a27bdf8d96327,

title = "Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer",

abstract = "CML is defined by the presence of an oncogenic fusion protein caused by a reciprocal translocation between chromosomes 9q and 22q. While our molecular understanding of CML pathogenesis has revolutionized drug development for this disease, we have yet to identify many predisposing factors for CML. Familial occurrence of CML has been rarely reported. Here, we describe 2 cases of CML in a 24-year-old woman and in her 73-year-old maternal great aunt. We describe genetic variants in these patients and report on their environmental exposures that may have contributed to CML pathogenesis. The possible familial association of these 2 cases of CML warrants further investigation into more definitive etiologies of this disease.",

keywords = "Chronic myeloid leukemia, Familial cancer, Hereditary cancer syndromes",

author = "Aitken, {Marisa J.L.} and Benton, {Christopher B.} and Issa, {Ghayas C.} and Koji Sasaki and Musa Yilmaz and Short, {Nicholas J.}",

note = "Funding Information: This work was supported in part by the Cancer Center Support Grant from the NIH/NCI, P30 CA016672. Publisher Copyright: {\textcopyright} 2021 S. Karger AG, Basel. Copyright: All rights reserved.",

year = "2021",

month = sep,

day = "1",

doi = "10.1159/000513925",

language = "English (US)",

volume = "144",

pages = "585--590",

journal = "Acta haematologica",

issn = "0001-5792",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer

AU - Aitken, Marisa J.L.

AU - Benton, Christopher B.

AU - Issa, Ghayas C.

AU - Sasaki, Koji

AU - Yilmaz, Musa

AU - Short, Nicholas J.

N1 - Funding Information: This work was supported in part by the Cancer Center Support Grant from the NIH/NCI, P30 CA016672. Publisher Copyright: © 2021 S. Karger AG, Basel. Copyright: All rights reserved.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - CML is defined by the presence of an oncogenic fusion protein caused by a reciprocal translocation between chromosomes 9q and 22q. While our molecular understanding of CML pathogenesis has revolutionized drug development for this disease, we have yet to identify many predisposing factors for CML. Familial occurrence of CML has been rarely reported. Here, we describe 2 cases of CML in a 24-year-old woman and in her 73-year-old maternal great aunt. We describe genetic variants in these patients and report on their environmental exposures that may have contributed to CML pathogenesis. The possible familial association of these 2 cases of CML warrants further investigation into more definitive etiologies of this disease.

AB - CML is defined by the presence of an oncogenic fusion protein caused by a reciprocal translocation between chromosomes 9q and 22q. While our molecular understanding of CML pathogenesis has revolutionized drug development for this disease, we have yet to identify many predisposing factors for CML. Familial occurrence of CML has been rarely reported. Here, we describe 2 cases of CML in a 24-year-old woman and in her 73-year-old maternal great aunt. We describe genetic variants in these patients and report on their environmental exposures that may have contributed to CML pathogenesis. The possible familial association of these 2 cases of CML warrants further investigation into more definitive etiologies of this disease.

KW - Chronic myeloid leukemia

KW - Familial cancer

KW - Hereditary cancer syndromes

UR - http://www.scopus.com/inward/record.url?scp=85103328048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85103328048&partnerID=8YFLogxK

U2 - 10.1159/000513925

DO - 10.1159/000513925

M3 - Article

C2 - 33735874

AN - SCOPUS:85103328048

SN - 0001-5792

VL - 144

SP - 585

EP - 590

JO - Acta haematologica

JF - Acta haematologica

IS - 5

ER -

Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this