TY - JOUR
T1 - Two cases of systemic mastocytosis with a lymphoma-like presentation
AU - Lubo-Julio, Idania
AU - Fermín-Santana, Ileana
AU - Lissia, Amelia
AU - Piras, María A.
AU - Massarelli, Giovannino
PY - 2013/7
Y1 - 2013/7
N2 - Mastocytosis is a group of clonal neoplastic disorders characterized by tissue proliferation of mastocytes morphologically and/or molecularly abnormal, being systemic when it has extracutaneous location. The clinical picture is variable and nonspecific. Cases have been described associated to other hematological neoplasms, especially those of myeloid and, to a lesser extent, lymphoid type. We present two cases of systemic mastocytosis involving bone marrow, lymph nodes and skin in elderly female patients which were initially diagnosed clinically as lymphoma. However, an abnormal proliferation in cumulus of mastocytes was identificated histologically using Giemsa and confirmed by CD117, CD25 and CD45. One of the patients had a rapid, unfavorable clinical evolution.
AB - Mastocytosis is a group of clonal neoplastic disorders characterized by tissue proliferation of mastocytes morphologically and/or molecularly abnormal, being systemic when it has extracutaneous location. The clinical picture is variable and nonspecific. Cases have been described associated to other hematological neoplasms, especially those of myeloid and, to a lesser extent, lymphoid type. We present two cases of systemic mastocytosis involving bone marrow, lymph nodes and skin in elderly female patients which were initially diagnosed clinically as lymphoma. However, an abnormal proliferation in cumulus of mastocytes was identificated histologically using Giemsa and confirmed by CD117, CD25 and CD45. One of the patients had a rapid, unfavorable clinical evolution.
KW - Lymphoma
KW - Mastocytosis
KW - Systemic mastocytosis
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U2 - 10.1016/j.patol.2012.09.004
DO - 10.1016/j.patol.2012.09.004
M3 - Article
AN - SCOPUS:84881231095
SN - 1699-8855
VL - 46
SP - 191
EP - 194
JO - Revista Espanola de Patologia
JF - Revista Espanola de Patologia
IS - 3
ER -