Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods

Nicholas J. Durr; Timothy Larson; Danielle K. Smith; Brian A. Korgel; Konstantin Sokolov; Adela Ben-Yakar

doi:10.1021/nl062962v

Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods

Nicholas J. Durr, Timothy Larson, Danielle K. Smith, Brian A. Korgel, Konstantin Sokolov, Adela Ben-Yakar

Imaging Physics

Research output: Contribution to journal › Article › peer-review

864 Scopus citations

Abstract

We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75μm deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.

Original language	English (US)
Pages (from-to)	941-945
Number of pages	5
Journal	Nano Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/nl062962v
State	Published - Apr 2007

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl062962v

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abstract = "We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75μm deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.",

author = "Durr, {Nicholas J.} and Timothy Larson and Smith, {Danielle K.} and Korgel, {Brian A.} and Konstantin Sokolov and Adela Ben-Yakar",

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T1 - Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods

AU - Durr, Nicholas J.

AU - Larson, Timothy

AU - Smith, Danielle K.

AU - Korgel, Brian A.

AU - Sokolov, Konstantin

AU - Ben-Yakar, Adela

PY - 2007/4

Y1 - 2007/4

N2 - We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75μm deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.

AB - We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75μm deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.

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Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods

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