Two-way traffic on the bridge from innate to adaptive immunity

Stephen E. Ullrich

doi:10.1038/jid.2010.139

Two-way traffic on the bridge from innate to adaptive immunity

Stephen E. Ullrich

Immunology

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Conventional wisdom suggests that information is usually transmitted from the dendritic cell (DC) to the T cell. In this issue, Schwarz and Schwarz demonstrate that UV-induced T regulatory cells (Tregs) can influence the biology of nave DC. They report that IL-10-secreting Tregs prime DC to activate additional Tregs when injected into nave mice. It may be possible to use DCs that have been educated by Tregs to induce immune tolerance in vivo.

Original language	English (US)
Pages (from-to)	1773-1775
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	130
Issue number	7
DOIs	https://doi.org/10.1038/jid.2010.139
State	Published - Jul 2010

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1038/jid.2010.139

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abstract = "Conventional wisdom suggests that information is usually transmitted from the dendritic cell (DC) to the T cell. In this issue, Schwarz and Schwarz demonstrate that UV-induced T regulatory cells (Tregs) can influence the biology of nave DC. They report that IL-10-secreting Tregs prime DC to activate additional Tregs when injected into nave mice. It may be possible to use DCs that have been educated by Tregs to induce immune tolerance in vivo.",

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AB - Conventional wisdom suggests that information is usually transmitted from the dendritic cell (DC) to the T cell. In this issue, Schwarz and Schwarz demonstrate that UV-induced T regulatory cells (Tregs) can influence the biology of nave DC. They report that IL-10-secreting Tregs prime DC to activate additional Tregs when injected into nave mice. It may be possible to use DCs that have been educated by Tregs to induce immune tolerance in vivo.

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Two-way traffic on the bridge from innate to adaptive immunity

Abstract

ASJC Scopus subject areas

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