TY - JOUR
T1 - Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses
AU - Iezzi, Giandomenica
AU - Boni, Andrea
AU - Degl'Innocenti, Elena
AU - Grioni, Matteo
AU - Bertilaccio, Maria T.S.
AU - Bellone, Matteo
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2006/8/15
Y1 - 2006/8/15
N2 - Activated CD8+ T cells can differentiate into type 1 (Tc1) cells, producing mainly IFN-γ, and type 2 (Tc2) cells, producing mostly IL-4, IL-5, and IL-10. Tc1 cells are potent CTL involved in the defense against intracellular pathogens and cancer cells. The role of Tc2 cells in the immune response is largely unknown, although their presence in chronic infections, cancer, and autoimmune diseases is associated with disease severity and progression. Here, we show that mouse Tc2 cells modify, through a cell-to-cell contact mechanism, the function of bone marrow-derived dendritic cells (DC). Indeed, Tc2-conditioned DC displayed a reduced expression of MHC class II and costimulatory molecules, produced IL-10 instead of IL-12, and favored the differentiation of both naive CD4+ and CD8+ T cells toward type 2 cells in the absence of added polarizing cytokines. The novel function for Tc2 cells suggests a type 2 loop in which Tc2 cells modify DC function and favor differentiation of naive T cells to type 2 cells. The type 2 loop may at least in part explain the unexpected high frequency of type 2 cells during a chronic exposure to the Ag.
AB - Activated CD8+ T cells can differentiate into type 1 (Tc1) cells, producing mainly IFN-γ, and type 2 (Tc2) cells, producing mostly IL-4, IL-5, and IL-10. Tc1 cells are potent CTL involved in the defense against intracellular pathogens and cancer cells. The role of Tc2 cells in the immune response is largely unknown, although their presence in chronic infections, cancer, and autoimmune diseases is associated with disease severity and progression. Here, we show that mouse Tc2 cells modify, through a cell-to-cell contact mechanism, the function of bone marrow-derived dendritic cells (DC). Indeed, Tc2-conditioned DC displayed a reduced expression of MHC class II and costimulatory molecules, produced IL-10 instead of IL-12, and favored the differentiation of both naive CD4+ and CD8+ T cells toward type 2 cells in the absence of added polarizing cytokines. The novel function for Tc2 cells suggests a type 2 loop in which Tc2 cells modify DC function and favor differentiation of naive T cells to type 2 cells. The type 2 loop may at least in part explain the unexpected high frequency of type 2 cells during a chronic exposure to the Ag.
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U2 - 10.4049/jimmunol.177.4.2131
DO - 10.4049/jimmunol.177.4.2131
M3 - Article
C2 - 16887972
AN - SCOPUS:33746932124
SN - 0022-1767
VL - 177
SP - 2131
EP - 2137
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -