UCbase & miRfunc: A database of ultraconserved sequences and microRNA function

Cristian Taccioli; Enrica Fabbri; Rosa Visone; Stefano Volinia; George A. Calin; Louise Y. Fong; Roberto Gambari; Arianna Bottoni; Mario Acunzo; John Hagan; Marilena V. Iorio; Claudia Piovan; Giulia Romano; Carlo Maria Croce

doi:10.1093/nar/gkn702

UCbase & miRfunc: A database of ultraconserved sequences and microRNA function

Cristian Taccioli, Enrica Fabbri, Rosa Visone, Stefano Volinia, George A. Calin, Louise Y. Fong, Roberto Gambari, Arianna Bottoni, Mario Acunzo, John Hagan, Marilena V. Iorio, Claudia Piovan, Giulia Romano, Carlo Maria Croce

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.

Original language	English (US)
Pages (from-to)	D41-D48
Journal	Nucleic acids research
Volume	37
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1093/nar/gkn702
State	Published - 2009

ASJC Scopus subject areas

Genetics

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title = "UCbase & miRfunc: A database of ultraconserved sequences and microRNA function",

abstract = "Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.",

author = "Cristian Taccioli and Enrica Fabbri and Rosa Visone and Stefano Volinia and Calin, {George A.} and Fong, {Louise Y.} and Roberto Gambari and Arianna Bottoni and Mario Acunzo and John Hagan and Iorio, {Marilena V.} and Claudia Piovan and Giulia Romano and Croce, {Carlo Maria}",

year = "2009",

doi = "10.1093/nar/gkn702",

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T1 - UCbase & miRfunc

T2 - A database of ultraconserved sequences and microRNA function

AU - Taccioli, Cristian

AU - Fabbri, Enrica

AU - Visone, Rosa

AU - Volinia, Stefano

AU - Calin, George A.

AU - Fong, Louise Y.

AU - Gambari, Roberto

AU - Bottoni, Arianna

AU - Acunzo, Mario

AU - Hagan, John

AU - Iorio, Marilena V.

AU - Piovan, Claudia

AU - Romano, Giulia

AU - Croce, Carlo Maria

PY - 2009

Y1 - 2009

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AB - Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.

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JO - Nucleic acids research

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IS - SUPPL. 1

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UCbase & miRfunc: A database of ultraconserved sequences and microRNA function

Abstract

ASJC Scopus subject areas

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