Ultraconserved long non-coding RNA uc.63 in breast cancer

Alberto Marini; Anna Maria Lena; Emanuele Panatta; Cristina Ivan; Leng Han; Han Liang; Margherita Annicchiarico-Petruzzelli; Nicola Di Daniele; George A. Calin; Eleonora Candi; Gerry Melino

doi:10.18632/oncotarget.10572

Ultraconserved long non-coding RNA uc.63 in breast cancer

Alberto Marini, Anna Maria Lena, Emanuele Panatta, Cristina Ivan, Leng Han, Han Liang, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, George A. Calin, Eleonora Candi, Gerry Melino

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.

Original language	English (US)
Pages (from-to)	35669-35680
Number of pages	12
Journal	Oncotarget
Volume	8
Issue number	22
DOIs	https://doi.org/10.18632/oncotarget.10572
State	Published - 2017

Keywords

Apoptosis
Breast cancer
LncRNA
Prognosis
T-UCRs

ASJC Scopus subject areas

Oncology

Access to Document

10.18632/oncotarget.10572

Cite this

@article{22b1e538206f45059a231462605532cc,

title = "Ultraconserved long non-coding RNA uc.63 in breast cancer",

abstract = "Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.",

keywords = "Apoptosis, Breast cancer, LncRNA, Prognosis, T-UCRs",

author = "Alberto Marini and Lena, {Anna Maria} and Emanuele Panatta and Cristina Ivan and Leng Han and Han Liang and Margherita Annicchiarico-Petruzzelli and Daniele, {Nicola Di} and Calin, {George A.} and Eleonora Candi and Gerry Melino",

note = "Publisher Copyright: {\textcopyright} Copyright Marini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2017",

doi = "10.18632/oncotarget.10572",

language = "English (US)",

volume = "8",

pages = "35669--35680",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals",

number = "22",

}

TY - JOUR

T1 - Ultraconserved long non-coding RNA uc.63 in breast cancer

AU - Marini, Alberto

AU - Lena, Anna Maria

AU - Panatta, Emanuele

AU - Ivan, Cristina

AU - Han, Leng

AU - Liang, Han

AU - Annicchiarico-Petruzzelli, Margherita

AU - Daniele, Nicola Di

AU - Calin, George A.

AU - Candi, Eleonora

AU - Melino, Gerry

N1 - Publisher Copyright: © Copyright Marini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2017

Y1 - 2017

N2 - Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.

AB - Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.

KW - Apoptosis

KW - Breast cancer

KW - LncRNA

KW - Prognosis

KW - T-UCRs

UR - http://www.scopus.com/inward/record.url?scp=85029430764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029430764&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.10572

DO - 10.18632/oncotarget.10572

M3 - Article

C2 - 27447964

AN - SCOPUS:85029430764

SN - 1949-2553

VL - 8

SP - 35669

EP - 35680

JO - Oncotarget

JF - Oncotarget

IS - 22

ER -

Ultraconserved long non-coding RNA uc.63 in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this