@inbook{e73078b404df40c897ab3c2da3901ced,
title = "Ultrahigh-Density Screens for Genome-Wide Yeast EMAPs in a Single Plate",
abstract = "Systematic measurements of genetic interactions have been used to classify gene functions and to categorize genes into protein complexes, functional pathways and biological processes. This protocol describes how to perform a high-throughput genetic interaction screen in S. cerevisiae using a variant of epistatic miniarray profiles (E-MAP) in which the fitnesses of 6144 colonies are measured simultaneously. We also describe the computational methods to analyze the resulting data.",
keywords = "EMAP, Genetic interactions, S-scores, Synthetic lethality, Ultrahigh-density yeast arrays",
author = "Katherine Licon and Shen, {John Paul} and Munson, {Brenton P.} and Manuel Michaca and Cole Fassino and Luke Fassino and Kreisberg, {Jason F.} and Trey Ideker",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019.",
year = "2019",
doi = "10.1007/978-1-4939-9736-7_4",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "73--85",
booktitle = "Methods in Molecular Biology",
}