Abstract
Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated. An ultrasonic beam was focused into a biological-tissue sample to modulate the laser light passing through the ultrasonic column inside the tissue. The contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging. Variation in the speckle contrast reflected optical inhomogeneity in the tissue. With this technique, two-dimensional images of biological-tissue samples of as much as 25 mm thick were successfully obtained with a low-power laser. The technique was experimentally compared with speckle-contrastbased, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6030-6035 |
| Number of pages | 6 |
| Journal | Applied Optics |
| Volume | 41 |
| Issue number | 28 |
| DOIs | |
| State | Published - Oct 1 2002 |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Engineering (miscellaneous)
- Electrical and Electronic Engineering