Abstract
Hematopoietic tissue-derived cells, including stem cells, have been shown to generate solid organ tissue-specific cells. Besides bone marrow and peripheral blood, umbilical cord blood (UCB) has the advantage of being an easily accessible stem cell source provided as a banked cell product. Using the xenogeneic human into NOD/SCID mouse stem cell transplant model preliminary data suggest UCB-derived tissue-specific cells generated in liver pancreas, CNS and endothelium. In a clinical sex-mismatched UCB transplant setting Y-positive, UCB-derived gastrointestinal epithelial cells and CNS-specific cells have been identified in female patients. The potential therapeutic use of UCB cells for tissue repair is, however, limited by a low total stem cell number available and by HLA-disparity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 258-261 |
| Number of pages | 4 |
| Journal | Cytotherapy |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2005 |
Keywords
- Regenerative medicine
- Stem cell transplantation
- Tissue repair
- Umbilical cord blood
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology
- Genetics(clinical)
- Cell Biology
- Cancer Research
- Transplantation