Umbilical Cord Blood Transplantation

Hind Rafei; Rohtesh S. Mehta; Betul Oran; Katayoun Rezvani; Elizabeth J. Shpall; Amanda Olson

doi:10.1016/B978-0-323-79833-4.00008-5

Umbilical Cord Blood Transplantation

Hind Rafei, Rohtesh S. Mehta, Betul Oran, Katayoun Rezvani, Elizabeth J. Shpall, Amanda Olson

Stem Cell Transplantation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cord blood transplantation (CBT) has emerged as a promising alternative for transplantation for patients lacking a matched peripheral blood or bone marrow donor and has witnessed major developments over the past two decades. Owing to the recent advances in the transplantation techniques and the implementation of evidence-based guidelines in the clinical transplantation practices, CBT now has outcomes comparable to those of other donor sources. Moreover, double CBT has been widely adopted. To overcome limitation of low cell doses available in single cords, innovative strategies to improve the application of CBT have been devised. In this chapter, we review the clinical practice of CBT and some of the major developments in the field.

Original language	English (US)
Title of host publication	Manual of Hematopoietic Cell Transplantation and Cellular Therapies
Publisher	Elsevier
Pages	101-114
Number of pages	14
ISBN (Electronic)	9780323798334
ISBN (Print)	9780323798341
DOIs	https://doi.org/10.1016/B978-0-323-79833-4.00008-5
State	Published - Jan 1 2023

Keywords

Conditioning regimen
Double cord blood transplant
Posttransplant complications
Transplantation
Umbilical cord blood

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-79833-4.00008-5

Cite this

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AU - Rafei, Hind

AU - Mehta, Rohtesh S.

AU - Oran, Betul

AU - Rezvani, Katayoun

AU - Shpall, Elizabeth J.

AU - Olson, Amanda

PY - 2023/1/1

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AB - Cord blood transplantation (CBT) has emerged as a promising alternative for transplantation for patients lacking a matched peripheral blood or bone marrow donor and has witnessed major developments over the past two decades. Owing to the recent advances in the transplantation techniques and the implementation of evidence-based guidelines in the clinical transplantation practices, CBT now has outcomes comparable to those of other donor sources. Moreover, double CBT has been widely adopted. To overcome limitation of low cell doses available in single cords, innovative strategies to improve the application of CBT have been devised. In this chapter, we review the clinical practice of CBT and some of the major developments in the field.

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KW - Posttransplant complications

KW - Transplantation

KW - Umbilical cord blood

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Umbilical Cord Blood Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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