TY - JOUR
T1 - Unbalanced expression of Fas and CD40 in mantle cell lymphoma
AU - Clodi, Katharina
AU - Snell, Virginia
AU - Zhao, Shourong
AU - Cabanillas, Fernando
AU - Andreeff, Michael
AU - Younes, Anas
PY - 1998
Y1 - 1998
N2 - B cells are characterized by the dual expression of CD40 and Fas receptors, which can mediate their survival and death, respectively. The balance between the dynamically opposing functions of these two receptors is important for B-cell selection, maturation and homeostasis. We found that mantle cell lymphoma (MCL) cells had a high level of CD40 and low or absent level of Fas, therefore favouring the CD40 cell survival pathway. Exogenous Fas ligand had no effect on MCL cells, whereas exogenous CD40 ligand enhanced their survival and rescued them from fludarabine-induced apoptosis. Our data raise the possibility that the prolonged survival of MCL cells in vivo may be explained by the unbalanced expression of Fas and CD40.
AB - B cells are characterized by the dual expression of CD40 and Fas receptors, which can mediate their survival and death, respectively. The balance between the dynamically opposing functions of these two receptors is important for B-cell selection, maturation and homeostasis. We found that mantle cell lymphoma (MCL) cells had a high level of CD40 and low or absent level of Fas, therefore favouring the CD40 cell survival pathway. Exogenous Fas ligand had no effect on MCL cells, whereas exogenous CD40 ligand enhanced their survival and rescued them from fludarabine-induced apoptosis. Our data raise the possibility that the prolonged survival of MCL cells in vivo may be explained by the unbalanced expression of Fas and CD40.
KW - Apoptosis
KW - CD40
KW - Fas
KW - Mantle cell lymphoma
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U2 - 10.1046/j.1365-2141.1998.00958.x
DO - 10.1046/j.1365-2141.1998.00958.x
M3 - Article
C2 - 9792311
AN - SCOPUS:0031656519
SN - 0007-1048
VL - 103
SP - 217
EP - 219
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -