TY - JOUR
T1 - Uncertainty analysis of quantitative imaging features extracted from contrast-enhanced CT in lung tumors
AU - Yang, Jinzhong
AU - Zhang, Lifei
AU - Fave, Xenia J.
AU - Fried, David V.
AU - Stingo, Francesco C.
AU - Ng, Chaan S.
AU - Court, Laurence E.
N1 - Funding Information:
This work was funded in part by National Cancer Institute grant R03CA178495-01 and the National Institutes of Health through Cancer Center Support Grant P30CA016672 . The authors would like to acknowledge Sarah Bronson and Dawn Chalaire from the Department of Scientific Publication at MD Anderson Cancer Center for reviewing the manuscript.
Funding Information:
This work was funded in part by National Cancer Institute grant R03CA178495-01 and the National Institutes of Health through Cancer Center Support Grant P30CA016672. The authors would like to acknowledge Sarah Bronson and Dawn Chalaire from the Department of Scientific Publication at MD Anderson Cancer Center for reviewing the manuscript.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Purpose: To assess the uncertainty of quantitative imaging features extracted from contrast-enhanced computed tomography (CT) scans of lung cancer patients in terms of the dependency on the time after contrast injection and the feature reproducibility between scans. Methods: Eight patients underwent contrast-enhanced CT scans of lung tumors on two sessions 2-days apart. Each session included 6 CT scans of the same anatomy taken every 15 s, starting 50 s after contrast injection. Image features based on intensity histogram, co-occurrence matrix, neighborhood gray-tone difference matrix, run-length matrix, and geometric shape were extracted from the tumor for each scan. Spearman's correlation was used to examine the dependency of features on the time after contrast injection, with values over 0.50 considered time-dependent. Concordance correlation coefficients were calculated to examine the reproducibility of each feature between times of scans after contrast injection and between scanning sessions, with values greater than 0.90 considered reproducible. Results: The features were found to have little dependency on the time between the contrast injection and the CT scan. Most features were reproducible between times of scans after contrast injection and between scanning sessions. Some features were more reproducible when they were extracted from a CT scan performed at a longer time after contrast injection. Conclusion: The quantitative imaging features tested here are mostly reproducible and show little dependency on the time after contrast injection.
AB - Purpose: To assess the uncertainty of quantitative imaging features extracted from contrast-enhanced computed tomography (CT) scans of lung cancer patients in terms of the dependency on the time after contrast injection and the feature reproducibility between scans. Methods: Eight patients underwent contrast-enhanced CT scans of lung tumors on two sessions 2-days apart. Each session included 6 CT scans of the same anatomy taken every 15 s, starting 50 s after contrast injection. Image features based on intensity histogram, co-occurrence matrix, neighborhood gray-tone difference matrix, run-length matrix, and geometric shape were extracted from the tumor for each scan. Spearman's correlation was used to examine the dependency of features on the time after contrast injection, with values over 0.50 considered time-dependent. Concordance correlation coefficients were calculated to examine the reproducibility of each feature between times of scans after contrast injection and between scanning sessions, with values greater than 0.90 considered reproducible. Results: The features were found to have little dependency on the time between the contrast injection and the CT scan. Most features were reproducible between times of scans after contrast injection and between scanning sessions. Some features were more reproducible when they were extracted from a CT scan performed at a longer time after contrast injection. Conclusion: The quantitative imaging features tested here are mostly reproducible and show little dependency on the time after contrast injection.
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U2 - 10.1016/j.compmedimag.2015.12.001
DO - 10.1016/j.compmedimag.2015.12.001
M3 - Article
C2 - 26745258
AN - SCOPUS:84958165658
SN - 0895-6111
VL - 48
SP - 1
EP - 8
JO - Computerized Medical Imaging and Graphics
JF - Computerized Medical Imaging and Graphics
ER -