Uncommon Cancers of the Bladder

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Micropapillary, sarcomatoid, and small cell carcinomas are uncommon, aggressive variants usually encountered in the evolution of high-grade nonpapillary transitional cell carcinoma (TCC). Of these, only small cell carcinoma is effectively treated with currently available systemic therapy. Adenocarcinoma and squamous cancers can also arise from the urothelium. Neither is as sensitive to chemotherapy as conventional TCC, but a subset (currently indefinable save in retrospect) does well. Dominant lymphoepithelioma has a favorable prognosis. Urachal cancers require preoperative recognition for optimal surgical management, and are being shown to be somewhat responsive to regimens useful in colon cancer. Mesenchymal tumors are exceedingly rare and are treated like other pelvic sarcomas.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer, Third Edition
PublisherJohn Wiley & Sons, Ltd
Number of pages9
ISBN (Print)0470012021, 9780470012024
StatePublished - Jul 11 2006


  • Lymphoepithelioma
  • Micropapillary
  • Sarcomatoid
  • Small cell
  • Urachal
  • Urothelium

ASJC Scopus subject areas

  • Medicine(all)


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