TY - JOUR
T1 - Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma
AU - Bilimoria, Malcolm M.
AU - Lauwers, Gregory Y.
AU - Doherty, Dorota A.
AU - Nagorney, David M.
AU - Belghiti, Jacques
AU - Do, Kim Anh
AU - Regimbeau, Jean Marc
AU - Ellis, Lee M.
AU - Curley, Steven A.
AU - Ikai, Iwao
AU - Yamaoka, Yoshio
AU - Vauthey, Jean Nicolas
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Hypothesis: A subset of patients can be identified who will survive without recurrence beyond 5 years after hepatic resection for hepatocellular carcinoma (HCC). Design: A retrospective review of a multi-institutional database of 591 patients who had undergone hepatic resection for HCC and on-site reviews of clinical records and pathology slides. Setting: All patients had been treated in academic referral centers within university-based hospitals. Patients: We identified 145 patients who had survived for 5 years or longer after hepatic resection for HCC. Main Outcome Measures: Clinical and pathologic factors, as well as scoring of hepatitis and fibrosis in the surrounding liver parenchyma, were assessed for possible association with survival beyond 5 years and cause of death among the 145 five-year survivors. Results: Median additional survival duration longer than 5 years was 4.1 years. Women had significantly longer median additional survival durations than did men (81 months vs 38 months, respectively, after the 5-year mark) (P=.008). Surgical margins, type of resection, an elevated preoperative α-fetoprotein level, and the presence of multiple tumors or microscopic vascular invasion had no bearing on survival longer than 5 years. However, patients who survived for 5 years who also had normal underlying liver or minimal fibrosis (score, 0-2) at surgery had significantly longer additional survival than did patients with moderate fibrosis (score, 3-4) or severe fibrosis/cirrhosis (score, 5-6) (P<.001). Conclusions: Death caused by HCC is rare beyond 5 years after resection of HCC in the absence of fibrosis or cirrhosis. The data suggest that chronic liver disease acts as a field of cancerization contributing to new HCC. These patients may benefit from therapies directed at the underlying liver disease.
AB - Hypothesis: A subset of patients can be identified who will survive without recurrence beyond 5 years after hepatic resection for hepatocellular carcinoma (HCC). Design: A retrospective review of a multi-institutional database of 591 patients who had undergone hepatic resection for HCC and on-site reviews of clinical records and pathology slides. Setting: All patients had been treated in academic referral centers within university-based hospitals. Patients: We identified 145 patients who had survived for 5 years or longer after hepatic resection for HCC. Main Outcome Measures: Clinical and pathologic factors, as well as scoring of hepatitis and fibrosis in the surrounding liver parenchyma, were assessed for possible association with survival beyond 5 years and cause of death among the 145 five-year survivors. Results: Median additional survival duration longer than 5 years was 4.1 years. Women had significantly longer median additional survival durations than did men (81 months vs 38 months, respectively, after the 5-year mark) (P=.008). Surgical margins, type of resection, an elevated preoperative α-fetoprotein level, and the presence of multiple tumors or microscopic vascular invasion had no bearing on survival longer than 5 years. However, patients who survived for 5 years who also had normal underlying liver or minimal fibrosis (score, 0-2) at surgery had significantly longer additional survival than did patients with moderate fibrosis (score, 3-4) or severe fibrosis/cirrhosis (score, 5-6) (P<.001). Conclusions: Death caused by HCC is rare beyond 5 years after resection of HCC in the absence of fibrosis or cirrhosis. The data suggest that chronic liver disease acts as a field of cancerization contributing to new HCC. These patients may benefit from therapies directed at the underlying liver disease.
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U2 - 10.1001/archsurg.136.5.528
DO - 10.1001/archsurg.136.5.528
M3 - Article
C2 - 11343543
AN - SCOPUS:0035014082
SN - 0004-0010
VL - 136
SP - 528
EP - 535
JO - Archives of Surgery
JF - Archives of Surgery
IS - 5
ER -