@article{d286612775ed40719308cd2386c6a455,
title = "Understanding radiation damage in late effect normal tissues: Learning to negotiate the dose-volume-complication terrain or waiting for godot?",
author = "Ling, {C. Clifton} and Kutcher, {Gerald J.} and Radhe Mohan",
note = "Funding Information: Acknowledgements-Supported in part by grant No. Pal-CA-59017 from the National Cancer Institute, National Insti-tutes of Health, DHHS, USA. The authors also benefited from The completeness and fidelity of the organ-specific DVH depends upon many factors, including the proper identification and delineation of the relevant structures, the accuracy of the dose algorithm, and the sufficiency of the calculation points. Although these issues appear conceptually simple, there are complexities; for example, improper tumor contouring could introduce an error in determining the volume of normal tissue irradiated, the appropriate region to delineate may not be obvious for some organs (e.g., the wall of the bladder), the 3D dose calculation may not be accurate amidst tissue inhomogeneity, and the statistics of the calculation points may be inadequate for small structures. With time and effort, however, it is expected that most of these will be resolved.",
year = "1995",
month = mar,
day = "30",
doi = "10.1016/0360-3016(95)00058-7",
language = "English (US)",
volume = "31",
pages = "1357--1360",
journal = "International journal of radiation oncology, biology, physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "5",
}