TY - JOUR
T1 - Understanding the cross-talk between ovarian tumors and immune cells
T2 - Mechanisms for effective immunotherapies
AU - Chiriva-Internati, Maurizio
AU - Mirandola, Leonardo
AU - Kast, W. Martin
AU - Jenkins, Marjorie R.
AU - Cobos, Everardo
AU - Cannon, Martin J.
PY - 2011/4
Y1 - 2011/4
N2 - Despite decades of research, ovarian cancer remains a lethal disease. Recent studies have reported the critical role played by the immune system in controlling growth and spread of ovarian tumors. Accordingly, immunotherapy has been indicated as the most likely successful new approach in the treatment of the disease. Unfortunately, ovarian cancer triggers immune inhibitory mechanisms that hamper anti-tumor responses. Therefore, future immunotherapies should be able to overcome these obstacles. Here we review the basic mechanisms of tumor immune surveillance with a particular focus on ovarian cancer, and we discuss cutting-edge strategies to promote immune system eradication of ovarian tumors.
AB - Despite decades of research, ovarian cancer remains a lethal disease. Recent studies have reported the critical role played by the immune system in controlling growth and spread of ovarian tumors. Accordingly, immunotherapy has been indicated as the most likely successful new approach in the treatment of the disease. Unfortunately, ovarian cancer triggers immune inhibitory mechanisms that hamper anti-tumor responses. Therefore, future immunotherapies should be able to overcome these obstacles. Here we review the basic mechanisms of tumor immune surveillance with a particular focus on ovarian cancer, and we discuss cutting-edge strategies to promote immune system eradication of ovarian tumors.
KW - Ovarian cancer
KW - T cells
KW - T-reg
KW - adoptive immunotherapies
KW - dendritic cells
KW - recombinant adeno-associated virus
UR - http://www.scopus.com/inward/record.url?scp=79955790524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955790524&partnerID=8YFLogxK
U2 - 10.3109/08830185.2011.561507
DO - 10.3109/08830185.2011.561507
M3 - Article
C2 - 21557635
AN - SCOPUS:79955790524
SN - 0883-0185
VL - 30
SP - 71
EP - 86
JO - International Reviews of Immunology
JF - International Reviews of Immunology
IS - 2-3
ER -