Abstract
A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4+ T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a subset CD4+ T cells, named T follicular helper (Tfh) cells, is critical to B-cell response induction. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4+ T-cell lineages, and the role of Tfh cells in health and disease.
Original language | English (US) |
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Pages (from-to) | 190-197 |
Number of pages | 8 |
Journal | Cellular and Molecular Immunology |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - May 2010 |
Keywords
- Bcl6
- IL-21
- T follicular helper (Tfh) cells
- autoimmunity
- costimulation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases