Understanding the lethal variant of prostate cancer: Power of examining extremes

Ana Aparicio; Christopher J. Logothetis; Sankar N. Maity

doi:10.1158/2159-8290.CD-11-0259

Understanding the lethal variant of prostate cancer: Power of examining extremes

Ana Aparicio, Christopher J. Logothetis, Sankar N. Maity

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN protooncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.

Original language	English (US)
Pages (from-to)	466-468
Number of pages	3
Journal	Cancer discovery
Volume	1
Issue number	6
DOIs	https://doi.org/10.1158/2159-8290.CD-11-0259
State	Published - Nov 2011

ASJC Scopus subject areas

Oncology

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title = "Understanding the lethal variant of prostate cancer: Power of examining extremes",

abstract = "Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN protooncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.",

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N2 - Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN protooncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.

AB - Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN protooncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.

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Understanding the lethal variant of prostate cancer: Power of examining extremes

Abstract

ASJC Scopus subject areas

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