TY - JOUR
T1 - Understanding the role of the gut microbiome in gastrointestinal cancer
T2 - A review
AU - Ağagündüz, Duygu
AU - Cocozza, Ermelinda
AU - Cemali, Özge
AU - Bayazıt, Ayşe Derya
AU - Nanì, Maria Francesca
AU - Cerqua, Ida
AU - Morgillo, Floriana
AU - Saygılı, Suna Karadeniz
AU - Berni Canani, Roberto
AU - Amero, Paola
AU - Capasso, Raffaele
N1 - Funding Information:
The paper was funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union—NextGenerationEU; Award Number: Project code PE00000003, Concession Decree No. 1550 of 11 October 2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title “ON Foods-Research and innovation network on food and nutrition Sustainability, Safety and Security—Working ON Foods.
Publisher Copyright:
Copyright © 2023 Ağagündüz, Cocozza, Cemali, Bayazıt, Nanì, Cerqua, Morgillo, Saygılı, Berni Canani, Amero and Capasso.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a genetic and multifactorial disease, influenced by the host and environmental factors. It has been stated that 20% of cancer is caused by microorganisms such as Helicobacter pylori, hepatitis B and C virus, and human papillomavirus. In addition to these well-known microorganisms associated with cancer, it has been shown differences in the composition of the microbiota between healthy individuals and cancer patients. Some studies have suggested the existence of the selected microorganisms and their metabolites that can promote or inhibit tumorigenesis via some mechanisms. Recent findings have shown that gut microbiome and their metabolites can act as cancer promotors or inhibitors. It has been shown that gastrointestinal cancer can be caused by a dysregulation of the expression of non-coding RNA (ncRNA) through the gut microbiome. This review will summarize the latest reports regarding the relationship among gut microbiome, ncRNAs, and gastrointestinal cancer. The potential applications of diagnosing and cancer treatments will be discussed.
AB - Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a genetic and multifactorial disease, influenced by the host and environmental factors. It has been stated that 20% of cancer is caused by microorganisms such as Helicobacter pylori, hepatitis B and C virus, and human papillomavirus. In addition to these well-known microorganisms associated with cancer, it has been shown differences in the composition of the microbiota between healthy individuals and cancer patients. Some studies have suggested the existence of the selected microorganisms and their metabolites that can promote or inhibit tumorigenesis via some mechanisms. Recent findings have shown that gut microbiome and their metabolites can act as cancer promotors or inhibitors. It has been shown that gastrointestinal cancer can be caused by a dysregulation of the expression of non-coding RNA (ncRNA) through the gut microbiome. This review will summarize the latest reports regarding the relationship among gut microbiome, ncRNAs, and gastrointestinal cancer. The potential applications of diagnosing and cancer treatments will be discussed.
KW - diagnosis
KW - gastrointestinal cancer
KW - microbiome
KW - non-coding RNAs
KW - therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85147454935&partnerID=8YFLogxK
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U2 - 10.3389/fphar.2023.1130562
DO - 10.3389/fphar.2023.1130562
M3 - Review article
C2 - 36762108
AN - SCOPUS:85147454935
SN - 1663-9812
VL - 14
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 1130562
ER -