TY - JOUR
T1 - Update on systemic treatment for newly diagnosed inflammatory breast cancer
AU - Chainitikun, Sudpreeda
AU - Saleem, Sadia
AU - Lim, Bora
AU - Valero, Vicente
AU - Ueno, Naoto T.
N1 - Publisher Copyright:
© 2021
PY - 2021/3
Y1 - 2021/3
N2 - Background: Inflammatory breast cancer (IBC) is a rare and aggressive disease, accounting for 2–4% of new cases of breast cancer. Owing to its aggressive nature, IBC represent approximately 8–10% of breast cancer deaths. Management of IBC requires a multidisciplinary team for decision-making involving a composite of systemic treatment, surgery, and radiation, or “Trimodality Treatment.” Because of the rarity of the disease, systemic therapy of IBC traditionally has been extrapolated from non-IBC clinical trials. Aim of Review: The purpose of this review is to provide an overview of the development of systemic treatment of IBC from the past to the present by focusing on IBC clinical trials, including chemotherapy and targeted therapies. Key Scientific Concepts of Review: We discuss their effects on pathologic complete response (pCR) and survival outcomes, the predictive markers, and the adverse events of these therapies. Further, we summarized the current standard treatment stratified by molecular subtypes based on clinical data. Finally, we discuss the future trend of systemic therapy, including immunotherapy and ongoing IBC clinical trials.
AB - Background: Inflammatory breast cancer (IBC) is a rare and aggressive disease, accounting for 2–4% of new cases of breast cancer. Owing to its aggressive nature, IBC represent approximately 8–10% of breast cancer deaths. Management of IBC requires a multidisciplinary team for decision-making involving a composite of systemic treatment, surgery, and radiation, or “Trimodality Treatment.” Because of the rarity of the disease, systemic therapy of IBC traditionally has been extrapolated from non-IBC clinical trials. Aim of Review: The purpose of this review is to provide an overview of the development of systemic treatment of IBC from the past to the present by focusing on IBC clinical trials, including chemotherapy and targeted therapies. Key Scientific Concepts of Review: We discuss their effects on pathologic complete response (pCR) and survival outcomes, the predictive markers, and the adverse events of these therapies. Further, we summarized the current standard treatment stratified by molecular subtypes based on clinical data. Finally, we discuss the future trend of systemic therapy, including immunotherapy and ongoing IBC clinical trials.
KW - Chemotherapy
KW - Immunotherapy
KW - Inflammatory breast cancer
KW - Systemic therapy
KW - Targeted therapy
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U2 - 10.1016/j.jare.2020.08.014
DO - 10.1016/j.jare.2020.08.014
M3 - Article
C2 - 33842000
AN - SCOPUS:85091826977
SN - 2090-1232
VL - 29
SP - 1
EP - 12
JO - Journal of Advanced Research
JF - Journal of Advanced Research
ER -