Abstract
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder triggered by a chromosomally induced mutation in a pluripotent stem cell. Its progressive clinical course consists of a chronic or benign phase, which terminates in blast crisis. Historically, treatment has been limited: conventional chemotherapy yields a median survival of approximately 36 to 42 months, and bone marrow transplantation, while achieving success in more than half of patients treated, is limited to younger patients with HLA-matched siblings. Treatment with interferon alfa in CML was initiated in 1981. The first studies were performed using partially pure interferon alfa; these studies were followed by treatment regimens employing interferon alfa-2a.
Original language | English (US) |
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Pages (from-to) | 31-36 |
Number of pages | 6 |
Journal | Seminars in hematology |
Volume | 27 |
Issue number | 3 SUPPL. 4 |
State | Published - 1990 |
ASJC Scopus subject areas
- Hematology