TY - JOUR
T1 - Updates on the hematologic tumor microenvironment and its therapeutic targeting
AU - Forte, Dorian
AU - Krause, Daniela S.
AU - Andreeff, Michael
AU - Bonnet, Dominique
AU - Méndez-Ferrer, Simón
N1 - Funding Information:
The authors apologize for the omission of relevant literature due to the focus of this review. The support of the European School of Hematology (ESH), Celgene, Janssen Oncology, Fluidigm and Cancer Research UK was critical for the organization of the Workshop on which this article is based. This work was supported by Bologna AIL and AIRC Associazione Italiana per la Ricerca sul Cancro with funding to DF, and core support grants from the Wellcome Trust and the Medical Research Council to the Cambridge Stem Cell Institute, National Health Service Blood and Transplant (United Kingdom), European Union’s Horizon 2020 Research (ERC-2014-CoG-64765) and a Programme Foundation Award from Cancer Research UK to SM-F.
Funding Information:
The authors apologize for the omission of relevant literature due to the focus of this review. The support of the European School of Hematology (ESH), Celgene, Janssen Oncology, Fluidigm and Cancer Research UK was critical for the organization of the Workshop on which this article is based. This work was supported by Bologna AIL and AIRC Associazione Italiana per la Ricerca sul Cancro with funding to DF, and core support grants from the Wellcome Trust and the Medical Research Council to the Cambridge Stem Cell Institute, National Health Service Blood and Transplant (United Kingdom), European Union's Horizon 2020 Research (ERC-2014-CoG-64765) and a Programme Foundation Award from Cancer Research UK to SM-F.
Publisher Copyright:
© 2019 Ferrata Storti Foundation.
PY - 2019
Y1 - 2019
N2 - In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. This review article is focused on recent scientific advances highlighted in the invited presentations at the meeting, which encompassed the normal and malignant niches supporting hematopoietic stem cells and their progeny. Given the precise focus, it does not discuss other relevant contributions in this field, which have been the scope of other recent reviews. The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. The review is structured in the following sections: (i) regulation of normal hematopoietic stem cell niches during development, adulthood and aging; (ii) metabolic adaptation and reprogramming in the tumor microenvironment; (iii) the key role of inflammation in reshaping the normal microenvironment and driving hematopoietic stem cell proliferation; (iv) current understanding of the tumor microenvironment in different malignancies, such as chronic lymphocytic leukemia, multiple myeloma, acute myeloid leukemia and myelodysplastic syndromes; and (v) the effects of therapies on the microenvironment and some opportunities to target the niche directly in order to improve current treatments.
AB - In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. This review article is focused on recent scientific advances highlighted in the invited presentations at the meeting, which encompassed the normal and malignant niches supporting hematopoietic stem cells and their progeny. Given the precise focus, it does not discuss other relevant contributions in this field, which have been the scope of other recent reviews. The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. The review is structured in the following sections: (i) regulation of normal hematopoietic stem cell niches during development, adulthood and aging; (ii) metabolic adaptation and reprogramming in the tumor microenvironment; (iii) the key role of inflammation in reshaping the normal microenvironment and driving hematopoietic stem cell proliferation; (iv) current understanding of the tumor microenvironment in different malignancies, such as chronic lymphocytic leukemia, multiple myeloma, acute myeloid leukemia and myelodysplastic syndromes; and (v) the effects of therapies on the microenvironment and some opportunities to target the niche directly in order to improve current treatments.
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U2 - 10.3324/haematol.2018.195396
DO - 10.3324/haematol.2018.195396
M3 - Review article
C2 - 31515356
AN - SCOPUS:85072848701
SN - 0390-6078
VL - 104
SP - 1928
EP - 1934
JO - Haematologica
JF - Haematologica
IS - 10
ER -