Abstract
The urachal ligament is an embryologic remnant connecting the dome of the bladder to the umbilicus via the ligamentum commune. Autopsy series suggest that in approximately a third of subjects, the urachal remnant may persist with tubular or cystic structures. However, tumors of this site are extremely rare. Patients usually present with hematuria and upon imaging, have evidence of a cystic or solid structure in the bladder dome or in the bladder midline. If a biospy confirms adenocarcinoma, these tumors should be considered an urachal cancer until proven otherwise. Although there are no prospective clinical trials reported to date, large single-institution reports suggest surgical resection with a partial cystectomy and en bloc resection of the urachal ligament with umbilicus as the treatment of choice in the setting of localized disease. Although there is currently no definitive role for neoadjuvant or adjuvant chemotherapy in this tumor, risk factors predicting progression may allow for the selection of patients who present with metastatic diesease that currently is not likely to be curable. There is no standard chemotherapy regimen for these patients; however, there is new-found hope with a currently accruing clinical trial exploring a 5-flourouracil-base chemotherapy combination in this patient population.
Original language | English (US) |
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Pages (from-to) | 1715-1721 |
Number of pages | 7 |
Journal | Expert review of anticancer therapy |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2006 |
Keywords
- 5-fluorouracil
- Adenocarcinoma
- Bladder cancer
- Chemotherapy
- Cisplatin
- Clinical trials
- Gemcitabine
- Surgery
- Urachal
ASJC Scopus subject areas
- Oncology
- Pharmacology (medical)